|国家预印本平台
首页|Do exercise-associated genes explain phenotypic variance in the three components of fitness? A Systematic review & Meta-analysis

Do exercise-associated genes explain phenotypic variance in the three components of fitness? A Systematic review & Meta-analysis

Do exercise-associated genes explain phenotypic variance in the three components of fitness? A Systematic review & Meta-analysis

来源:bioRxiv_logobioRxiv
英文摘要

ABSTRACT The aim of this systematic review and meta-analysis was to identify a list of common, candidate genes associated with the three components of fitness, specifically cardiovascular fitness, muscular strength, and anaerobic power, and how these genes are associated with exercise response phenotype variability, in previously untrained participants. A total of 3,969 potentially relevant papers were identified and processed for inclusion. After eligibility and study selection assessment, 24 studies were selected for meta-analysis, comprising a total of 3,012 participants. Meta-Essentials spreadsheet 1.4 (Microsoft Excel) was used in creating the forest plots and meta-analysis. IBM SPSS statistics V24 was implemented for the statistical analyses and the alpha was set at p ≤ 0.05. 13 candidate genes and their associated alleles were identified, which were associated with the phenotypes of interest. Analysis of training group data showed significant differential phenotypic responses. Subgroup analysis showed; 44%, 72% and 10% of the response variance in aerobic, strength and power phenotypes, respectively, were explained by genetic influences. This analysis established that genetic variability explained a significant proportion of the adaptation differences across the three components of fitness in the participants post-training. The results also showed the importance of analysing and reporting specific gene alleles. Information obtained from these findings has the potential to inform and influence future exercise-related genes and training studies.

Chung Henry C、Gordon Dan A、Keiller Don R、Roberts Justin D

Cambridge Centre for Sport & Exercise Sciences, Anglia Ruskin UniversityCambridge Centre for Sport & Exercise Sciences, Anglia Ruskin UniversitySchool of Life Sciences, Anglia Ruskin UniversityCambridge Centre for Sport & Exercise Sciences, Anglia Ruskin University

10.1101/2021.03.22.436402

体育生物科学研究方法、生物科学研究技术遗传学

Chung Henry C,Gordon Dan A,Keiller Don R,Roberts Justin D.Do exercise-associated genes explain phenotypic variance in the three components of fitness? A Systematic review & Meta-analysis[EB/OL].(2025-03-28)[2025-05-23].https://www.biorxiv.org/content/10.1101/2021.03.22.436402.点此复制

评论