Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125
Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125
Abstract Expression of long non-coding RNA KIAA0125 has been incorporated in various gene expression signatures for prognostic prediction in acute myeloid leukemia (AML) patients, yet its functions and clinical significance remain unclear. This study was aimed to investigate the clinical and biological characteristics of AML bearing different levels of KIAA0125. We profiled KIAA0125 expression levels in bone marrow cells from 347 de novo AML patients and found higher KIAA0125 expression was closely associated with FLT3-ITD, RUNX1, and DNMT3A mutations, and M1 subtype by the French-American-British classification, but inversely correlated with t(8;21) and t(15;17). Among the 227 patients who received standard chemotherapy, those with higher KIAA0125 expression had a lower complete remission rate, shorter overall survival (OS) and disease-free survival (DFS) than those with lower expression. The prognostic significance was validated in both TCGA and GSE12417 cohorts. Subgroup analyses showed that higher KIAA0125 expression also predicted shorter DFS and OS in patients with normal karyotype or non-M3 AML. In multivariable analysis, higher KIAA0125 expression remained an adverse risk factor independent of age, WBC counts, karyotypes, and mutation patterns. Bioinformatics analyses revealed that higher KIAA0125 expression was associated with hematopoietic and leukemic stem cell signatures and ATP-binding cassette transporters, two predisposing factors for chemoresistance.
Lee Sze-Hwei、Chou Wen-Chien、Hsu Chia-Lang、Hung Sheng-Yu、Hou Hsin-An、Lin Chien-Chin、Tsai Cheng-Hong、Wang Yu-Hung、Yao Chi-Yuan、Tien Hwei-Fang
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University||Tai-Cheng Stem Cell Therapy Center, National Taiwan UniversityDivision of Hematology, Department of Internal Medicine||Department of Laboratory MedicineDepartment of Laboratory Medicine, Department of Medical Research, National Taiwan University HospitalDivision of Hematology, Department of Internal Medicine, National Taiwan University Hospital Yunlin BranchDivision of Hematology, Department of Internal MedicineGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University||Division of Hematology, Department of Internal Medicine||Department of Laboratory MedicineDivision of Hematology, Department of Internal MedicineGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University||Division of Hematology, Department of Internal MedicineDepartment of Laboratory Medicine||Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital Yunlin BranchDivision of Hematology, Department of Internal Medicine
基础医学肿瘤学生物科学研究方法、生物科学研究技术
Lee Sze-Hwei,Chou Wen-Chien,Hsu Chia-Lang,Hung Sheng-Yu,Hou Hsin-An,Lin Chien-Chin,Tsai Cheng-Hong,Wang Yu-Hung,Yao Chi-Yuan,Tien Hwei-Fang.Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125[EB/OL].(2025-03-28)[2025-04-28].https://www.medrxiv.org/content/10.1101/2020.08.21.20179267.点此复制
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