|国家预印本平台
首页|Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS during glial injury signalling in Drosophila

Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS during glial injury signalling in Drosophila

Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS during glial injury signalling in Drosophila

来源:bioRxiv_logobioRxiv
英文摘要

Glial immunity plays a pivotal role in the maintenance of nervous system homeostasis and in responses to stress conditions, including neural injuries. The transcription factor Stat92E is activated independently of the canonical JAK/STAT pathway in Drosophila glial cells following central nervous system injury to shape glial reactivity towards degenerating axons. However, the upstream regulatory mechanisms governing Stat92E activation remain elusive. Here we reveal that selective autophagy mediates degradation of the PIAS SUMO ligase family member Stat92E repressor, Su(var)2-10 in glia. Autophagic elimination of Su(var)2-10 mediated by its co-localization and interaction with the core autophagy factor Atg8a is required for efficient Stat92E-dependent transcription after injury. In line with this, we demonstrate that autophagy is essential for the upregulation of an innate immune pathway in glial cells following axon injury, characterized by the induction of virus-induced RNA 1 (vir-1). We propose that autophagic Su(var)2-10 breakdown controls Stat92E activation to allow glial reactivity. These findings identify a critical role for autophagy in glial immunity as part of neural injury responses.

Szab¨? ¨¢ron、Vincze Vir¨¢g、Feh¨|r-Juh¨¢sz Erzs¨|bet、Jipa Andr¨¢s、Feil-B?rcs?k Dalma、Juh¨¢sz G¨¢bor、Chhatre Aishwarya Sanjay、Esk¨1dt Zsombor、Galambos Anna Rita、Csord¨?s Martin

10.1101/2024.08.28.610109

细胞生物学遗传学分子生物学

Szab¨? ¨¢ron,Vincze Vir¨¢g,Feh¨|r-Juh¨¢sz Erzs¨|bet,Jipa Andr¨¢s,Feil-B?rcs?k Dalma,Juh¨¢sz G¨¢bor,Chhatre Aishwarya Sanjay,Esk¨1dt Zsombor,Galambos Anna Rita,Csord¨?s Martin.Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS during glial injury signalling in Drosophila[EB/OL].(2025-03-28)[2025-05-13].https://www.biorxiv.org/content/10.1101/2024.08.28.610109.点此复制

评论