Central nervous system immune response in postinfectious hydrocephalus
Central nervous system immune response in postinfectious hydrocephalus
ABSTRACT Inflammation following neonatal infection is a dominant cause of childhood hydrocephalus in the developing world. Understanding this complex inflammatory response is critical for the development of preventive therapies. In 100 African hydrocephalic infants ≤3 months of age, with and without a history of infection, we elucidated the biological pathways that account for this inflammatory response. We integrated proteomics and RNA sequencing in cerebrospinal fluid, identifying gene pathways involving neutrophil, interleukin (4, 12, and 13) and interferon activity associated with this condition. These findings are required to develop strategies to reduce the risk of hydrocephalus during treatment of infection.
Limbrick David D. Jr、Onen Justin、Hornig Mady、Zhang Qiang、Morton Sarah U.、Mulondo Ronnie、Paulson Joseph N.、Movassagh Mercedeh、Isaacs Albert M.、Schiff Steven J.、Morales Diego M.、Warf Benjamin C.、Ericson Jessica E、Broach James R.、Kabachelor Edith、Townsend R Reid、Sinnar Shamim A.、Hehnly Christine、Zhang Lijun、Ssenyonga Peter
Department of Neurosurgery, Washington University School of MedicineCURE Children?ˉs Hospital of UgandaDepartment of Epidemiology, Columbia University Mailman School of Public HealthDepartment of Medicine, Washington University School of MedicineDivision of Newborn Medicine, Boston Children?ˉs Hospital||Department of Pediatrics, Harvard Medical SchoolCURE Children?ˉs Hospital of UgandaDepartment of Biostatistics, Product Development, Genentech IncDepartment of Biostatistics, Harvard T.H. Chan School of Public HealthDepartment of Neuroscience, Washington University School of Medicine||Department of Clinical Neurosciences, University of CalgaryCenter for Neural Engineering, Pennsylvania State University||Department of Engineering Science and Mechanics, Pennsylvania State University||The Center for Infectious Disease Dynamics, Pennsylvania State University||Department of Neurosurgery, Pennsylvania State University College of Medicine||Department of Physics, Pennsylvania State UniversityDepartment of Neurosurgery, Washington University School of MedicineDepartment of Neurosurgery, Harvard Medical SchoolDepartment of Pediatrics, Pennsylvania State College of MedicineInstitute for Personalized Medicine, Pennsylvania State University||Department of Biochemistry and Molecular Biology, Pennsylvania State UniversityCURE Children?ˉs Hospital of UgandaDepartment of Medicine, Washington University School of MedicineCenter for Neural Engineering, Pennsylvania State University||Department of Medicine, Pennsylvania State University College of MedicineInstitute for Personalized Medicine, Pennsylvania State University||Department of Biochemistry and Molecular Biology, Pennsylvania State UniversityInstitute for Personalized Medicine, Pennsylvania State UniversityCURE Children?ˉs Hospital of Uganda
基础医学神经病学、精神病学医学研究方法
Limbrick David D. Jr,Onen Justin,Hornig Mady,Zhang Qiang,Morton Sarah U.,Mulondo Ronnie,Paulson Joseph N.,Movassagh Mercedeh,Isaacs Albert M.,Schiff Steven J.,Morales Diego M.,Warf Benjamin C.,Ericson Jessica E,Broach James R.,Kabachelor Edith,Townsend R Reid,Sinnar Shamim A.,Hehnly Christine,Zhang Lijun,Ssenyonga Peter.Central nervous system immune response in postinfectious hydrocephalus[EB/OL].(2025-03-28)[2025-04-30].https://www.medrxiv.org/content/10.1101/2020.07.30.20165332.点此复制
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