Comparative and population genomics analyses of eared pheasants inhabiting highly varying altitudes
Comparative and population genomics analyses of eared pheasants inhabiting highly varying altitudes
Abstract Oxygen pressure varies dramatically with altitudes on Earth; however, humans and animals thrive at almost all altitudes. To better understand genetic basis underlying adaptation of closely related species to varying altitudes, we annotated and compared the genome of a white eared pheasant (WT) (Crossoptilon crossoptilon) inhabiting high altitudes and the genome of a brown eared pheasant (BR) (C. mantchuricum) inhabiting low altitudes, and found that the WT genome harbors 967 more genes but 457 fewer pseudogenes than the BR genome. Moreover, we compared genetic variations in populations of WT and BR as well as of blue eared pheasants (BL) (C. auritum) inhabiting intermediate altitudes, and identified thousands of selective sweeps in each species. Intriguingly, the unique genes and pseudogenes in the two genomes converge on the same set of altitude adaptation-related pathways of four functional categories as genes in selective sweeps in each species. Thus, these species appear to adapt to highly varying altitudes by diverging selection on the same traits via loss-of-function mutations and fine-tuning genes in common pathways.
Wang Kun、Wu Dong-Dong、Su Zhengchang、Dou Tengfei、Wu Siwen、Ge Xuehai、Ge Changrong、Yuan Sisi、Jia Junjing
Faculty of Animal Science and Technology, Yunnan Agricultural University||State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesDepartment of Bioinformatics and Genomics, College of Computing and Informatics, the University of North Carolina at CharlotteFaculty of Animal Science and Technology, Yunnan Agricultural UniversityDepartment of Bioinformatics and Genomics, College of Computing and Informatics, the University of North Carolina at CharlotteFaculty of Animal Science and Technology, Yunnan Agricultural UniversityFaculty of Animal Science and Technology, Yunnan Agricultural UniversityDepartment of Bioinformatics and Genomics, College of Computing and Informatics, the University of North Carolina at CharlotteFaculty of Animal Science and Technology, Yunnan Agricultural University
遗传学动物学生物科学现状、生物科学发展
Wang Kun,Wu Dong-Dong,Su Zhengchang,Dou Tengfei,Wu Siwen,Ge Xuehai,Ge Changrong,Yuan Sisi,Jia Junjing.Comparative and population genomics analyses of eared pheasants inhabiting highly varying altitudes[EB/OL].(2025-03-28)[2025-05-17].https://www.biorxiv.org/content/10.1101/2024.05.21.595214.点此复制
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