Transient disruption of the inferior parietal lobule impairs the ability to attribute intention to action
Transient disruption of the inferior parietal lobule impairs the ability to attribute intention to action
Abstract Although it is well established that fronto-parietal regions are active during action observation, whether they play a causal role in the ability to infer others’ intentions from visual kinematics remains undetermined. In experiments reported here, we combined offline continuous theta-burst stimulation (cTBS) with computational modeling to reveal single-trial computations in the inferior parietal lobule (IPL) and inferior frontal gyrus (IFG). Participants received cTBS over the left anterior IPL and the left IFG pars orbitalis, in separate sessions, before completing an intention discrimination task (discriminate intention of observed reach-to-grasp acts) or a kinematic discrimination task (discriminate peak wrist height of the same acts) unrelated to intention. We targeted intentions-sensitive regions whose fMRI-measured activity accurately discriminated intention from the same action stimuli. We found that transient disruption of activity of the left IPL, but not the IFG, impaired the observer’s ability to judge intention from movement kinematics. Kinematic discrimination unrelated to intention, in contrast, was largely unaffected. Computational analyses revealed that IPL cTBS did not impair the ability to ‘see’ changes in movement kinematics, nor did it alter the weight given to informative versus non-informative kinematic features. Rather, it selectively impaired the ability to link variations in informative features to the correct intention. These results provide the first causal evidence that left anterior IPL maps kinematics to intentions.
Koul Atesh、Cavallo Andrea、Patri Jean-Fran?ois、Avenanti Alessio、Soriano Marco、Valente Martina、Pullar Kiri、Panzeri Stefano、Becchio Cristina
Cognition, Motion & Neuroscience, Center for Human Technologies, Istituto Italiano di TecnologiaCognition, Motion & Neuroscience, Center for Human Technologies, Istituto Italiano di Tecnologia||Department of Psychology, University of TurinCognition, Motion & Neuroscience, Center for Human Technologies, Istituto Italiano di Tecnologia||Neural Computation Laboratory, Center for Human Technologies, Istituto Italiano di Tecnologia GenoaCenter for Studies and Research in Cognitive Neuroscience, Department of Psychology, University of Bologna||Centro de Investigaci¨?n en Neuropsicolog¨aa y Neurociencias Cognitivas, Universidad Cat¨?lica del MauleCognition, Motion & Neuroscience, Center for Human Technologies, Istituto Italiano di Tecnologia||Department of Psychology, University of TurinNeural Computation Laboratory, Center for Human Technologies, Istituto Italiano di Tecnologia Genoa||Center for Mind/Brain Sciences (CIMeC), University of TrentoCognition, Motion & Neuroscience, Center for Human Technologies, Istituto Italiano di Tecnologia||Neural Computation Laboratory, Center for Human Technologies, Istituto Italiano di Tecnologia GenoaNeural Computation Laboratory, Center for Human Technologies, Istituto Italiano di Tecnologia GenoaCognition, Motion & Neuroscience, Center for Human Technologies, Istituto Italiano di Tecnologia
生物科学研究方法、生物科学研究技术生理学人类学
Koul Atesh,Cavallo Andrea,Patri Jean-Fran?ois,Avenanti Alessio,Soriano Marco,Valente Martina,Pullar Kiri,Panzeri Stefano,Becchio Cristina.Transient disruption of the inferior parietal lobule impairs the ability to attribute intention to action[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2020.04.18.047787.点此复制
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