The Unexpected Match: STAT3-NORAD Interaction, a Novel Link in Antiviral Defense
The Unexpected Match: STAT3-NORAD Interaction, a Novel Link in Antiviral Defense
In the intricate biological landscape, evolution often repurposes familiar elements for novel roles. This study reveals an interaction between the long non-coding RNA NORAD, noted for its role in DNA stability, and the immune-related transcription factor STAT3. Our findings indicate that NORAD’s binding to STAT3 facilitates its nuclear entry, suppressing the antiviral response. In the absence of NORAD, STAT3 remains cytoplasmic, enabling STAT1 to activate this response. Evidence from viral infections and clinical samples reinforces this unique role for NORAD. Intriguingly, while other functions of NORAD are conserved in evolution, this newly discovered role is unique to humans, owing to the introduction of an ALU element in hominoids. This discovery sheds new light on the evolution of antiviral defenses.
Shalev Dor、Polyak Galia、Biran Hadas、Hashimshony Tamar、Argoetti Amir、Shima Noa、Mandel-Gutfreund Yael、Lahav Tamar
Technion ¨C Israel Institute of Technology, Faculty of BiologyTechnion ¨C Israel Institute of Technology, Faculty of BiologyTechnion ¨C Israel Institute of Technology, Faculty of Computer ScienceTechnion ¨C Israel Institute of Technology, Faculty of BiologyTechnion ¨C Israel Institute of Technology, Faculty of BiologyTechnion ¨C Israel Institute of Technology, Faculty of BiologyTechnion ¨C Israel Institute of Technology, Faculty of Biology||Technion ¨C Israel Institute of Technology, Faculty of Computer ScienceTechnion ¨C Israel Institute of Technology, Faculty of Biology
基础医学分子生物学生物科学研究方法、生物科学研究技术
Shalev Dor,Polyak Galia,Biran Hadas,Hashimshony Tamar,Argoetti Amir,Shima Noa,Mandel-Gutfreund Yael,Lahav Tamar.The Unexpected Match: STAT3-NORAD Interaction, a Novel Link in Antiviral Defense[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2023.06.29.546999.点此复制
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