Parasite hybridization promotes spreading of endosymbiotic viruses
Parasite hybridization promotes spreading of endosymbiotic viruses
ABSTRACT Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of endosymbiotic viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis parasites and their endosymbiotic Leishmania RNA virus. We show that parasite populations circulate in isolated pockets of suitable habitat and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites were geographically and ecologically dispersed, and commonly infected from a pool of genetically diverse viruses. Our results suggest that parasite hybridization, likely due to increased human migration and ecological perturbations, increased the frequency of endosymbiotic interactions known to play a key role in disease severity.
Beverley Stephen M、Heeren Senne、Lye Lon-Fye、Arevalo Jorge、Llanos-Cuentas Alejandro、Dujardin Jean-Claude、Van den Broeck Frederik、Cotton James A、Garcia Lineth、Sanders Mandy、Maes Ilse、Lemey Philippe
Department of Molecular Microbiology, Washington University School of MedicineDepartment of Biomedical Sciences, Institute of Tropical Medicine||Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven||Department of Biomedical Sciences, University of AntwerpDepartment of Molecular Microbiology, Washington University School of MedicineInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano HerediaInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano HerediaDepartment of Biomedical Sciences, Institute of Tropical Medicine||Department of Biomedical Sciences, University of AntwerpDepartment of Biomedical Sciences, Institute of Tropical Medicine||Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit LeuvenParasite Genomics Group, Welcome Sanger InstituteInstituto de Investigaci¨?n Biom¨|dicas e Investigaci¨?n Social, Universidad Mayor de San SimonParasite Genomics Group, Welcome Sanger InstituteDepartment of Biomedical Sciences, Institute of Tropical MedicineDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven
医学研究方法基础医学皮肤病学、性病学
Beverley Stephen M,Heeren Senne,Lye Lon-Fye,Arevalo Jorge,Llanos-Cuentas Alejandro,Dujardin Jean-Claude,Van den Broeck Frederik,Cotton James A,Garcia Lineth,Sanders Mandy,Maes Ilse,Lemey Philippe.Parasite hybridization promotes spreading of endosymbiotic viruses[EB/OL].(2025-03-28)[2025-06-30].https://www.biorxiv.org/content/10.1101/2023.03.24.534103.点此复制
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