Projections of non-invasive human recordings into state space show unfolding of spontaneous and over-trained choice
Projections of non-invasive human recordings into state space show unfolding of spontaneous and over-trained choice
Abstract Choices rely on a transformation of sensory inputs into motor responses. Using invasive single neuron recordings, the evolution of a choice process has been tracked by projecting population neural responses into state spaces. Here we develop an approach that allows us to recover state space trajectories on a millisecond timescale in non-invasive human recordings. We selectively suppress activity related to relevant and irrelevant sensory inputs and response direction in magnetoencephalography data acquired during context-dependent choices. Recordings from premotor cortex show a smooth progression from sensory input encoding to response encoding. In contrast to previous macaque recordings, information related to choice-irrelevant features is represented more weakly than choice-relevant sensory information. To test whether this mechanistic difference between species is caused by extensive overtraining common in non-human primate studies, we trained humans on >20,000 trials of the task. Choice-irrelevant features were still weaker than relevant features in premotor cortex after overtraining.
Woolrich Mark W、Takagi Yu、Behrens Timothy EJ、Klein-Fl¨1gge Miriam C、Hunt Laurence
Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Nuffield Department of Clinical Neurosciences John Radcliffe Hospital||Department of Psychiatry, University of Oxford, Warneford HospitalWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology University of Oxford||Department of Psychiatry, University of Oxford, Warneford Hospital||Department of Neuropsychiatry, Graduate School of Medicine, University of TokyoWellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Nuffield Department of Clinical Neurosciences John Radcliffe Hospital||Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London (UCL)Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology University of Oxford||Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Nuffield Department of Clinical Neurosciences John Radcliffe HospitalWellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Nuffield Department of Clinical Neurosciences John Radcliffe Hospital||Department of Psychiatry, University of Oxford, Warneford Hospital
生物科学研究方法、生物科学研究技术生物物理学生理学
Woolrich Mark W,Takagi Yu,Behrens Timothy EJ,Klein-Fl¨1gge Miriam C,Hunt Laurence.Projections of non-invasive human recordings into state space show unfolding of spontaneous and over-trained choice[EB/OL].(2025-03-28)[2025-06-22].https://www.biorxiv.org/content/10.1101/2020.02.24.962290.点此复制
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