ETP/TaqIB基因多态性与训练敏感性的关联研究

Objective—To explore the association between the allele frequency of the single nucleotide polymorphism TaqIΒ in the intron of the cholesteryl ester transfer protein (CETP) gene and aerobic capacity as well as the sensitivity for endurance training. Methods—102 male soldiers, who were from northern China, undertook a distance running program, which consisted of 5000 m running with the intensity of 95-105% ventilatory threshold (VT), 3 times/week for 18 wk. VO2max and VT were measured on a treadmill before and after the protocol, and cholesteryl ester transfer protein gene polymorphism was detected by PCR-RFLP. Results—The genotype frequencies were as follows: B1B1=36%，B1B2=42%，B2B2=22% and they were in Hardy－Weinberg equilibrium. The present study found that the genotype distribution was not different among Occidental, Japanese，Korea and Chinese people, but it was significantly different from America-Africa Negro. After training, there was a significant difference between B1B2 and B2B2 genotype, the group with B2B2 genotype was much lower than B1B2. Conclusions—The result indicated that the TaqIB of CETP was related with endurance training sensitivity, B2B2 genotype might contribute to individual differences in endurance training.