GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy
GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy
ABSTRACT IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular deposition of IgA. We performed a genome-wide association study involving 10,146 kidney biopsy-diagnosed IgAN cases and 28,751 matched controls across 17 international cohorts. We defined 30 independent genome-wide significant risk loci jointly explaining 11% of disease risk. A total of 16 loci were novel, including TNFSF4, REL, CD28, CXCL8/PF4V1, LY86, LYN, ANXA3, TNFSF8/15, REEP3, ZMIZ1, RELA, ETS1, IGH, IRF8, TNFRSF13B and FCAR. The SNP-based heritability of IgAN was estimated at 23%. We observed a positive genetic correlation between IgAN and total serum IgA levels, allergy, tonsillectomy, and several infections, and a negative correlation with inflammatory bowel disease. All significant non-HLA loci shared with serum IgA levels had a concordant effect on the risk of IgAN. Moreover, IgAN loci were globally enriched in gene orthologs causing abnormal IgA levels when genetically manipulated in mice. The explained heritability was enriched in the regulatory elements of cells from the immune and hematopoietic systems and intestinal mucosa, providing support for the pathogenic role of extra-renal tissues. The polygenic risk of IgAN was associated with early disease onset, increased lifetime risk of kidney failure, as well as hematuria and several other traits in a phenome-wide association study of 590,515 individuals. In the comprehensive functional annotation analysis of candidate causal genes across genome-wide significant loci, we observed the convergence of biological candidates on a common set of inflammatory signaling pathways and cytokine ligand-receptor pairs, prioritizing potential new drug targets.
Stengel Benedicte、Mizerska-Wasiak Malgorzata、Cho BeLong、Bomback Andrew S.、Trimarchi Hernan、Smoyer William、Hidalgo Guillermo、Weng Patricia、Davis Keefe、Vasylyeva Tetyana L.、Huerta Ana、Ballarin Jose、Lundberg Sigrid、Vogt Bruno、Caliskan Yasar、Barratt Jonathan、Abeygunaratne Thilini、Rauen Thomas、Floege J¨1rgen、Schlosser Pascal、Cattran Daniel C.、Reich Heather、Ravani Pietro、Galesic Kresimir、Berthoux Francois、Zanoni Francesca、Khan Atlas、Marasa Maddalena、Balderes Olivia、Fontaine Bertrand、Kim Dong Ki、Franke Andre、Annese Vito、Harley John B、Kim Yon Su、Park Jin-Ho、Ranch Daniel、Wenderfer Scott E.、Nagy Judit、Amoroso Antonio、Battaglia Giovanni Giorgio、Boer Emanuela、Bono Luisa、Xie Jingyuan、Loos Ruth J. F.、Ionita-Laza Iuliana、Julian Bruce、Scolari Francesco、Zhang Hong、Heleniak Zbigniew、Dyga Katarzyna、Siniewicz-Luze¨?czyk Katarzyna、Runowski Dariusz、Kwella Norbert、Van Wijk Ans、Tkaczyk Marcin、Ghiggeri GianMarco、Coppo Rosanna、Feriozzi Sandro、Frasca Giovanni、Garozzo Maurizio、Mitrotti Adele、Granata Simona、Londrino Francesco、Delbarba Elisa、Mucha Krzysztof、P?czek Leszek、Moszczuk Barbara、Pa¨?czyk-Tomaszewska Malgorzata、Pani Antonello、Salvadori Maurizio、Savoldi Silvana、Izzi Claudia、Alberici Federico、Magnano Andrea、Messa Piergiorgio、Perkowska-Ptasi¨?ska Agnieszka、Durlik Magdalena、Pawlaczyk Krzysztof、Sikora Przemyslaw、Kuzmiuk-Glembin Izabella、Gregersen Peter K.、Hryszko Tomasz、Canetta Pietro A.、Gale Daniel P.、Kiryluk Krzysztof、Berthelot Laureline、Gembillo Guido、Lifton Richard P.、Zaniew Marcin、Salvi Erica、Appel Gerald B.、Canaud Guillaume、van Heel David、Kottyan Leah、Stangou Maria、Gharavi Ali G.、Bodria Monica、Materna-Kiryluk Anna、Cotsapas Chris、Marcantoni Carmelita、Pei York、Barlassina Cristina、Lee Hajeong、Mladkova Nikol、Sreedharan Raji、Dro?d? Dorota、Tesar Vladimir、B?czkowska Teresa、Kenny Eimear E.、Krajewska Magdalena、Spotti Donatella、Liu Lili、Weirauch Matthew、D?bska-Slizien Alicja、Prikhodina Larisa、Niemczyk Stanis?aw、Galliani Marco、Novak Jan、Kalra Philip A.、Eckardt Kai-Uwe、Quiroga Alejandro、Samsonov Dmitry、Zhou Xu-jie、Kovacs Tibor、Esposito Vittoria、Kaminska Dorota、Ars Elisabet、Mignani Renzo、Machura Edyta、Rheault Michelle、Bullo-Piontecka Barbara、Caridi Gianluca、Suzuki Hitoshi、Wyatt Robert、Goumenos Dimitrios、Florczak Micha?、Chen Nan、Parameswaran Sreeja、Ponticelli Claudio、Vecchio Lucia Del、Zhang Jun Y.、Kronenberg Florian、Roccatello Dario、Pisani Isabella、Mani Laila-Yasmin、Sanna-Cherchi Simone、Cusi Daniele、K?ttgen Anna、Mahan John、Fiaccadori Enrico、Ekici Arif B.、Magistroni Riccardo、Krata Natalia、Habura Ireneusz、Sanchez-Rodriguez Elena、Claes Donna J.、Miklaszewska Monika、Panzer Ulf、Wijmenga Cisca、Sprangers Ben、Peruzzi Licia、Polci Rosaria、Liberek Tomasz、Oleh Akchurin、Selewski David、Zamboli Pasquale、Lugani Francesca、Santoro Domenico、Pawlak-Bratkowska Monika、Goto Shin、Gesualdo Loreto、Radhakrishnan Jai、Metzger Marie、Szczepa¨?ska Maria、Pillebout Evangeline、Boscutti Giuliano、Zaza Gianluigi、Narita Ichiei、Kallash Mahmoud、Chishti Aftab、Esposito Ciro、Samhar Al-Akash、Maixnerova Dita、Choi Murim、Maillard Nicolas、Nelson Raoul、Monteiro Renato
Centre for Research in Epidemiology and Population Health (CESP), Paris-Saclay University, Versailles Saint Quentin UniversityDepartment of Pathology, Medical University of WarsawInstitute on Aging, Seoul National University College of Medicine||Amsterdam University Medical Centre, VU University Medical Center (VUMC) locationDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityNephrology Service, Hospital Brit¨￠nico de Buenos AiresDivision of Pediatric Nephrology, Nationwide Children?ˉs HospitalDivision of Pediatric Nephrology, Department of Pediatrics, HMH Hackensack University Medical CenterDivision of Pediatric Nephrology, Medical College of WisconsinDivision of Pediatric Nephrology, SUNY BuffaloDivision of Pediatric Nephrology, University of MinnesotaMolecular Biology Laboratory and Nephrology Department, Fundaci¨? Puigvert, Instituto de Investigaciones Biom¨|dicas Sant Pau, Universitat Aut¨°noma de BarcelonaDepartment of Nephrology, Danderyd University Hospital, and Department of Clinical Sciences, Karolinska InstitutetDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of BernDivision of Nephrology, Saint Louis UniversityJohn Walls Renal Unit, University Hospitals of LeicesterNational Institute of Health ResearchSalford Royal HospitalInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of FreiburgInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of FreiburgInstitute of Human Genetics, Friedrich-Alexander-Universit?t Erlangen-N¨1rnbergDepartment of Nephrology, University of Toronto, Toronto General HospitalDepartment of Nephrology, University of Toronto, Toronto General HospitalDivision of Nephrology, Department of Internal Medicine, University of CalgaryZagreb Medical SchoolNephrology, Dialysis, and Renal Transplantation Department, University North HospitalDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityAssistance Publique-H?pitaux de Paris (AP-HP), Service of Neuro-Myology, University Hospital Pitie-Salpetriere||Departments of Neurology and Genetics, Yale UniversityBiomedical Science, Seoul National University College of MedicineCBP American HospitalRobert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health SystemDepartment of Nephrology, Juntendo University Faculty of MedicineDepartment of Family Medicine, Seoul National University College of Medicine and Seoul National University HospitalInstitute on Aging, Seoul National University College of MedicineDivision of Pediatric Nephrology, Baylor College of Medicine/Texas Children?ˉs HospitalDivision of Pediatric Nephrology, Boston Children?ˉs HospitalDepartment of Medicine and Surgery, University of Parma, ParmaRenal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, San Paolo Hospital, School of Medicine, University of MilanUniversity of MessinaNephrology and Dialysis, A.R.N.A.S. Civico and BenfratellioNephrology, Dialysis and Renal Transplant Unit, S. Maria della Misericordia HospitalDepartment of Genetics, Yale School of MedicineNovo Nordisk Foundation Center for Basic Metabolic Research, Department of Health and Medical Sciences, University of Copenhagen||Department of Genetics and Genomic Sciences, Mount Sinai Health SystemDepartments of Microbiology and Medicine, University of Alabama at BirminghamDepartment of Immunology, Transplantology and Internal Diseases, Medical University of WarsawRenal Division, Peking University First Hospital, Peking University Institute of Nephrology2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of BialystokDepartment of Pediatrics, Immunology and Nephrology, Polish Mother?ˉs Memorial Hospital Research InstituteDepartment of Nephrology, Kidney Transplantation and Hypertension, Children?ˉs Memorial Health InstituteDepartment of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in OlsztynDepartment of Pediatric Nephrology and Hypertension, Jagiellonian University Medical CollegeHospital Universitario Puerta del Hierro MajadahondaDepartment of Nephrology, Kidney Transplantation and Hypertension, Children?ˉs Memorial Health InstituteRegina Margherita Children?ˉs HospitalICS Maugeri SpA, University of PaviaDivision of Nephrology, Dialysis and Renal Transplantation, Riuniti HospitalSandro Pertini HospitalNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo MoroRenal Unit, Department of Medicine, University of VeronaS. Andrea HospitalDepartment of Surgical, Medical, Dental, Oncologic and Regenerative Medicine, University of Modena and Reggio EmiliaDepartment of Immunology, Transplantology and Internal Diseases, Medical University of WarsawInstitute of Biochemistry and Biophysics, Polish Academy of Sciences||Department of Internal Disease, Nephrology and Dialysotherapy, Military Institute of MedicineInstitute of Biochemistry and Biophysics, Polish Academy of Sciences||Department of Internal Disease, Nephrology and Dialysotherapy, Military Institute of MedicineInstitute of Biochemistry and Biophysics, Polish Academy of Sciences||Department of Pediatrics and Nephrology, Medical University of WarsawDepartment of Pathology, Medical University of WarsawNephrology and Dialysis,Ospedale MaggioreRenal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of MilanSan Raffaele HospitalDepartment of Immunology, Transplantology and Internal Diseases, Medical University of WarsawDepartment of Immunology, Transplantology and Internal Diseases, Medical University of WarsawNephrology Division, San Marco HospitalAzienda Unit¨¤ Sanitaria Locale RiminiDepartment of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of WarsawDepartment of Nephrology, Transplantology and Internal Medicine, Poznan Medical UniversityDepartment of Pediatric Nephrology Medical University of LublinDepartment of Pediatrics, University of Zielona G¨?ra2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of BialystokCincinnati Children?ˉs Hospital Medical CenterDepartment of Genetics, Medical University of PoznanDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityUniversity of HamburgDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia University||Institute for Genomic Medicine, Columbia UniversityCRTI UMR1064, Inserm, Nantes UniversityUnit of Nephrology and Dialysis ASL TO4Laboratory of Human Genetics and Genomics, The Rockefeller University||The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiClinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical UniversityUnit of Nephrology and Dialysis, AOU G Martino, University of MessinaDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityUniversit¨| de Paris, H?pital Necker¨CEnfants MaladesSorbonne University, INSERM. Center of Research in Myology - UMR 974, Institute of Myology, University Hospital Pitie-SalpetriereUniversity of Cincinnati College of Medicine||US Department of Veterans Affairs Medical Center, Cincinnati, OH and Cincinnati Educational and Research for Veterans Foundation2nd Department of Internal Medicine, Nephrological and Diabetological Center, University of P¨|csDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia University||Institute for Genomic Medicine, Columbia UniversityDivision of Nephrology and Dialysis, Gorizia HospitalDepartment of Pediatric Nephrology and Hypertension, Jagiellonian University Medical CollegeUniversity of GroningenNephrology Dialysis and Kidney Transplant Unit, Fundazione IRCCS Ca?ˉ Granda Ospedale Maggiore Policlinico, Universit¨¤ degli studi di MilanoDepartment of Nephrology, University of Toronto, Toronto General HospitalDepartment of Nephrology and dialysis, ASST LarianaBiomedical Science, Seoul National University College of MedicineDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityDivision of Pediatric Nephrology, Mott Children?ˉs HospitalDepartment of Nephrology, Karol Marcinkowski Hospital1st Faculty of Medicine and General University Hospital,Charles UniversityDepartment of Nephrology, Transplantology and Internal Medicine, Poznan Medical UniversityNovo Nordisk Foundation Center for Basic Metabolic Research, Department of Health and Medical Sciences, University of Copenhagen||Center for Population Genomic Health, Icahn School of Medicine at Mount Sinai||Department of Biostatistics, Mailman School of Public Health, Columbia UniversityDepartment of Nephrology, Transplantology and Internal Diseases, Medical University of GdanskNephroCare ItalyDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityUniversity of Cincinnati College of Medicine||US Department of Veterans Affairs Medical Center, Cincinnati, OH and Cincinnati Educational and Research for Veterans Foundation2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of BialystokBarts and The London School of Medicine and Dentistry, Queen Mary University of LondonDepartment of Clinical Immunology, Medical University of WarsawUnit¨¤ Operativa di Nefrologia e Dialisi, Ospedale di AcirealeSalford Royal HospitalDepartment of Nephrology and Hypertension, Friedrich-Alexander-Universit?t Erlangen-N¨1rnberg||Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDivision of Pediatric Nephrology, Mattel Children?ˉs HospitalDivision of Pediatric Nephrology, Department of Pediatrics, New York Medical CollegeRenal Division, Peking University First Hospital, Peking University Institute of NephrologyDepartment of Medicine and Surgery, University of Parma, ParmaBelcolle HospitalDepartment of Nephrology, Transplantology and Internal Diseases, Medical University of GdanskDepartment of Nephrology, Danderyd University Hospital, and Department of Clinical Sciences, Karolinska InstitutetDepartment of Nephrology and Dialysis, G. Brotzu HospitalDepartment of Pediatrics, Immunology and Nephrology, Polish Mother?ˉs Memorial Hospital Research InstituteDivision of Pediatric Nephrology, University of Kentucky2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of BialystokRegina Margherita Children?ˉs HospitalDivision of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental SciencesDivision of Pediatric Nephrology, University of Tennessee Health Sciences Center||Children?ˉs Foundation Research Center, Le Bonheur Children?ˉs Hospital2nd Department of Internal Medicine, Nephrological and Diabetological Center, University of P¨|csInstitute of Biochemistry and Biophysics, Polish Academy of SciencesDepartment of Genetics, Yale School of MedicineUniversity of Cincinnati College of MedicineNephrology and Dialysis Unit, G. Bosco Hub Hospital (ERK-net Member) and University of TorinoUnit¨¤ Operativa di Nefrologia e Dialisi, Ospedale di AcirealeDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityDivision of Inherited & Acquired Kidney Diseases, Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical UniversityDivision of Nephrology and Renal Transplantation, Carreggi HospitalNephrology Division, San Marco HospitalDivision of Nephrology, Saint Louis UniversityDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia University||Institute for Genomic Medicine, Columbia UniversityDepartment of Nephrology and dialysis, ASST LarianaInstitute of Human Genetics, Friedrich-Alexander-Universit?t Erlangen-N¨1rnbergDivision of Pediatric Nephrology, Nationwide Children?ˉs HospitalDepartment of Medical Sciences, University of TurinDepartment of Nephrology and Medical Intensive Care, Charit¨|-Universit?tsmedizin BerlinDepartment of Medicine and Surgery, University of ParmaInstitute of Biochemistry and Biophysics, Polish Academy of SciencesInstitute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of InnsbruckDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityDivision of Pediatric Nephrology, Cornell UniversityDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in KatowiceDivision of Nephrology and Clinical Immunology, RWTH Aachen UniversityInstitute of Clinical Molecular Biology, Christian-Albrechts-University of KielDepartment of Microbiology and Immunology, Laboratory of Molecular Immunology, KU Leuven||Division of Nephrology, University Hospitals LeuvenICS Maugeri SpA, University of PaviaDivision of Nephrology, Dialysis and Renal Transplantation, Riuniti Hospital2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of BialystokThe Aristotle University of ThessalonikiDivision of Pediatric Nephrology, Department of Pediatrics, the Medical University of South Carolina (MUSC)Department of Medical and Surgical Specialties and Nephrology Unit, University of Brescia ¨C ASST Spedali CiviliICS Maugeri SpA, University of PaviaUnit of Nephrology and Dialysis ASL TO4Department of Nephrology, Kidney Transplantation and Hypertension, Children?ˉs Memorial Health InstituteInternal Medicine, Seoul National University College of MedicineRenal Unit, Department of Medicine, University of VeronaDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia UniversityCentre for Research in Epidemiology and Population Health (CESP), Paris-Saclay University, Versailles Saint Quentin UniversityDepartment of Pediatrics, Immunology and Nephrology, Polish Mother?ˉs Memorial Hospital Research InstituteCenter for Research on Inflammation, University of ParisDivision of Nephrology, Dialysis and Transplantation, IRCCS Giannina Gaslini InstituteS. Andrea HospitalInternal Medicine, Seoul National University College of MedicineDivision of Pediatric Nephrology, Department of Pediatrics, Nationwide Children?ˉs HospitalDivision of Pediatric Nephrology, Department of Pediatrics, University of KentuckyBelcolle HospitalDivision of Pediatric Nephrology, Driscoll Children?ˉs Hospital1st Faculty of Medicine and General University Hospital,Charles UniversityDepartment of Family Medicine, Seoul National University College of Medicine and Seoul National University HospitalNephrology, Dialysis, and Renal Transplantation Department, University North HospitalDivision of Pediatric Nephrology, Department of Pediatrics, University of UtahCenter for Research on Inflammation, University of Paris
医学研究方法基础医学内科学
Stengel Benedicte,Mizerska-Wasiak Malgorzata,Cho BeLong,Bomback Andrew S.,Trimarchi Hernan,Smoyer William,Hidalgo Guillermo,Weng Patricia,Davis Keefe,Vasylyeva Tetyana L.,Huerta Ana,Ballarin Jose,Lundberg Sigrid,Vogt Bruno,Caliskan Yasar,Barratt Jonathan,Abeygunaratne Thilini,Rauen Thomas,Floege J¨1rgen,Schlosser Pascal,Cattran Daniel C.,Reich Heather,Ravani Pietro,Galesic Kresimir,Berthoux Francois,Zanoni Francesca,Khan Atlas,Marasa Maddalena,Balderes Olivia,Fontaine Bertrand,Kim Dong Ki,Franke Andre,Annese Vito,Harley John B,Kim Yon Su,Park Jin-Ho,Ranch Daniel,Wenderfer Scott E.,Nagy Judit,Amoroso Antonio,Battaglia Giovanni Giorgio,Boer Emanuela,Bono Luisa,Xie Jingyuan,Loos Ruth J. F.,Ionita-Laza Iuliana,Julian Bruce,Scolari Francesco,Zhang Hong,Heleniak Zbigniew,Dyga Katarzyna,Siniewicz-Luze¨?czyk Katarzyna,Runowski Dariusz,Kwella Norbert,Van Wijk Ans,Tkaczyk Marcin,Ghiggeri GianMarco,Coppo Rosanna,Feriozzi Sandro,Frasca Giovanni,Garozzo Maurizio,Mitrotti Adele,Granata Simona,Londrino Francesco,Delbarba Elisa,Mucha Krzysztof,P?czek Leszek,Moszczuk Barbara,Pa¨?czyk-Tomaszewska Malgorzata,Pani Antonello,Salvadori Maurizio,Savoldi Silvana,Izzi Claudia,Alberici Federico,Magnano Andrea,Messa Piergiorgio,Perkowska-Ptasi¨?ska Agnieszka,Durlik Magdalena,Pawlaczyk Krzysztof,Sikora Przemyslaw,Kuzmiuk-Glembin Izabella,Gregersen Peter K.,Hryszko Tomasz,Canetta Pietro A.,Gale Daniel P.,Kiryluk Krzysztof,Berthelot Laureline,Gembillo Guido,Lifton Richard P.,Zaniew Marcin,Salvi Erica,Appel Gerald B.,Canaud Guillaume,van Heel David,Kottyan Leah,Stangou Maria,Gharavi Ali G.,Bodria Monica,Materna-Kiryluk Anna,Cotsapas Chris,Marcantoni Carmelita,Pei York,Barlassina Cristina,Lee Hajeong,Mladkova Nikol,Sreedharan Raji,Dro?d? Dorota,Tesar Vladimir,B?czkowska Teresa,Kenny Eimear E.,Krajewska Magdalena,Spotti Donatella,Liu Lili,Weirauch Matthew,D?bska-Slizien Alicja,Prikhodina Larisa,Niemczyk Stanis?aw,Galliani Marco,Novak Jan,Kalra Philip A.,Eckardt Kai-Uwe,Quiroga Alejandro,Samsonov Dmitry,Zhou Xu-jie,Kovacs Tibor,Esposito Vittoria,Kaminska Dorota,Ars Elisabet,Mignani Renzo,Machura Edyta,Rheault Michelle,Bullo-Piontecka Barbara,Caridi Gianluca,Suzuki Hitoshi,Wyatt Robert,Goumenos Dimitrios,Florczak Micha?,Chen Nan,Parameswaran Sreeja,Ponticelli Claudio,Vecchio Lucia Del,Zhang Jun Y.,Kronenberg Florian,Roccatello Dario,Pisani Isabella,Mani Laila-Yasmin,Sanna-Cherchi Simone,Cusi Daniele,K?ttgen Anna,Mahan John,Fiaccadori Enrico,Ekici Arif B.,Magistroni Riccardo,Krata Natalia,Habura Ireneusz,Sanchez-Rodriguez Elena,Claes Donna J.,Miklaszewska Monika,Panzer Ulf,Wijmenga Cisca,Sprangers Ben,Peruzzi Licia,Polci Rosaria,Liberek Tomasz,Oleh Akchurin,Selewski David,Zamboli Pasquale,Lugani Francesca,Santoro Domenico,Pawlak-Bratkowska Monika,Goto Shin,Gesualdo Loreto,Radhakrishnan Jai,Metzger Marie,Szczepa¨?ska Maria,Pillebout Evangeline,Boscutti Giuliano,Zaza Gianluigi,Narita Ichiei,Kallash Mahmoud,Chishti Aftab,Esposito Ciro,Samhar Al-Akash,Maixnerova Dita,Choi Murim,Maillard Nicolas,Nelson Raoul,Monteiro Renato.GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy[EB/OL].(2025-03-28)[2025-05-24].https://www.medrxiv.org/content/10.1101/2021.11.19.21265383.点此复制
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