Changes in non-oscillatory features of the cortical sensorimotor rhythm in Parkinson’s disease across age
Changes in non-oscillatory features of the cortical sensorimotor rhythm in Parkinson’s disease across age
Abstract Parkinson’s disease (PD) is associated with changes in neural activity in the sensorimotor alpha and beta bands. Using magnetoencephalography (MEG), we investigated the role of spontaneous neuronal activity within the somatosensory cortex in a large cohort of early-to mid-stage PD patients (N = 78) and age- and sex matched healthy controls (N = 60) using source reconstructed resting-state MEG. We quantified features of the time series data in terms of oscillatory alpha power, beta power, and 1/f broadband characteristics using power spectral density, and also characterised transient beta burst events in the time-domain signals. We examined the relationship between these signal features and the patients’ disease state, symptom severity, age, sex, and cortical thickness. PD patients and healthy controls differed on PSD broadband characteristics, with PD patients showing a steeper 1/f exponential slope and higher 1/f offset. PD patients further showed a steeper age-related decrease in the burst rate. Out of all the signal features of the sensorimotor activity, only burst rate was associated with increased severity of bradykinesia. Our study shows that general non-oscillatory features (broadband PSD slope and offset) of the sensorimotor signals are related to disease state and oscillatory burst rate scales with symptom severity in PD.
Ingvar Martin、Vinding Mikkel C.、Eriksson Allison、Ferreira Daniel、Svenningsson Per、Waldthaler Josefine、Ting Low Cassia Man、Lundqvist Daniel
NatMEG, Department of Clinical Neuroscience, Karolinska InstitutetNatMEG, Department of Clinical Neuroscience, Karolinska InstitutetNatMEG, Department of Clinical Neuroscience, Karolinska Institutet||Department of Women?ˉs and Children?ˉs Health, Uppsala UniversityDivision of Clinical Geriatrics, Center for Alzheimer?ˉs Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet||Department of Radiology, Mayo ClinicSection of Neurology, Department of Clinical Neuroscience, Karolinska InstitutetSection of Neurology, Department of Clinical Neuroscience, Karolinska Institutet||Department of Neurology, University Hospital MarburgNatMEG, Department of Clinical Neuroscience, Karolinska Institutet||Cognitive Neuroimaging Centre, Lee Kong Chien School of Medicine, Nanyang Technological UniversityNatMEG, Department of Clinical Neuroscience, Karolinska Institutet
神经病学、精神病学基础医学医学研究方法
Ingvar Martin,Vinding Mikkel C.,Eriksson Allison,Ferreira Daniel,Svenningsson Per,Waldthaler Josefine,Ting Low Cassia Man,Lundqvist Daniel.Changes in non-oscillatory features of the cortical sensorimotor rhythm in Parkinson’s disease across age[EB/OL].(2025-03-28)[2025-05-22].https://www.medrxiv.org/content/10.1101/2021.06.27.21259592.点此复制
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