Repeated evolution of circadian clock dysregulation in cavefish populations
Repeated evolution of circadian clock dysregulation in cavefish populations
Abstract Circadian rhythms are nearly ubiquitous throughout nature, suggesting they are critical for survival in diverse environments. Organisms inhabiting environments with arrhythmic days, such as caves, offer a unique opportunity to study the evolution of circadian rhythms in response to changing ecological pressures. Here we demonstrate that the cave environment has led to the repeated disruption of the biological clock across multiple populations of Mexican cavefish, with the circadian transcriptome showing widespread reductions in rhythmicity and changes to the timing of the activation/repression of genes in the core pacemaker. Then, we investigate the function of two genes with decreased rhythmic expression in cavefish. Mutants of these genes phenocopy reductions in sleep seen in multiple cave populations, suggesting a link between circadian dysregulation and sleep reduction. Altogether, our results reveal that evolution in an arrhythmic environment has resulted in dysregulation to the biological clock across multiple populations by diverse molecular mechanisms.
McGaugh Suzanne E.、Passow Courtney N.、Stanhope Bethany A.、Ferrufino Estephany、Tsuchiya Dai、Slaughter Brian D.、Kowalko Johanna、Rohner Nicolas、Keene Alex C.、Persons Jenna L.、Jaggard James B.、Smith Sarah E.、Mack Katya L.
Ecology, Evolution, and Behavior, University of MinnesotaEcology, Evolution, and Behavior, University of MinnesotaDepartment of Biological Sciences, Florida Atlantic UniversityDepartment of Biological Sciences, Florida Atlantic UniversityStowers Institute for Medical ResearchStowers Institute for Medical ResearchWilkes Honors College, Florida Atlantic UniversityStowers Institute for Medical Research||Department of Molecular and Integrative Physiology, The University of Kansas Medical CenterDepartment of Biological Sciences, Florida Atlantic UniversityStowers Institute for Medical ResearchDepartment of Biological Sciences, Florida Atlantic UniversityStowers Institute for Medical ResearchBiology, Stanford University
生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术遗传学生理学分子生物学
McGaugh Suzanne E.,Passow Courtney N.,Stanhope Bethany A.,Ferrufino Estephany,Tsuchiya Dai,Slaughter Brian D.,Kowalko Johanna,Rohner Nicolas,Keene Alex C.,Persons Jenna L.,Jaggard James B.,Smith Sarah E.,Mack Katya L..Repeated evolution of circadian clock dysregulation in cavefish populations[EB/OL].(2025-03-28)[2025-07-01].https://www.biorxiv.org/content/10.1101/2020.01.14.906628.点此复制
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