Post-reactivation new learning impairs and updates human episodic memory through dissociable processes
Post-reactivation new learning impairs and updates human episodic memory through dissociable processes
Abstract Learning of competing information after reactivation has the potential to disrupt memory reconsolidation and thus impair a consolidated memory. Yet this effect has rarely been detected in episodic memory. By introducing an additional retrieving cue to the target memory, the current study detected significant impairment on the reactivated episodic memory, in addition to an integration of new information to the old memory. However, while the integration effect followed the time window of reconsolidation disruption, the impairment effect did not. MEG measurements further revealed alpha power change during reactivation and post-reactivation learning which showed different correlation patterns with the integration and impairment effects, confirming that the two effects relied on different processes. Therefore, post-reactivation new learning disrupts episodic memory but not through reconsolidation disruption. Further findings that the impairment effect was correlated with participants’ voluntary inhibition ability suggest an inhibition-based memory updating process underlying post-reactivation new learning.
Jia Jianrong、Zhu Zijian、Wang Yingying、Wu Yanhong、Huang Liqiang、Rao Yi
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University||IDG/McGovern Institute for Brain Research, Peking UniversityPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University||IDG/McGovern Institute for Brain Research, Peking UniversityPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University||IDG/McGovern Institute for Brain Research, Peking UniversitySchool of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University||Key Laboratory of Machine Perception (Ministry of Education), Peking UniversityDepartment of Psychology, The Chinese University of Hong KongPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University||IDG/McGovern Institute for Brain Research, Peking University||Beijing Innovation Center for Genomics, Peking University
生物科学理论、生物科学方法生物科学研究方法、生物科学研究技术普通生物学
Jia Jianrong,Zhu Zijian,Wang Yingying,Wu Yanhong,Huang Liqiang,Rao Yi.Post-reactivation new learning impairs and updates human episodic memory through dissociable processes[EB/OL].(2025-03-28)[2025-04-29].https://www.biorxiv.org/content/10.1101/320101.点此复制
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