雄性大鼠心肌组织运动抗衰老候选基因在果蝇物种中的基因保守性分析

Screened in male rats may be related to age-related novel gene，Through the knowledge of bioinformatics to look at the homologous gene in Drosophila. Method: In the NCBI database，To find out the homologous gene of male rats in Drosophila, The first step must make a mparison analysis of protein sequence by the Blast program, and find the similarity of the target sequence in Drosophila Through the Comparison with sequence of rat. the next step is the pediction and analysis about protein structure by SMART, Comparison of gene function in order to confirm the homology genes in Drosophila. Conclusion: The 18 genes in male rats there are 10 genes to find the homology genes in Drosophila. These genes include: Grm8、Slc22a2、Slc5a5、Grin1、Prkcz、Gna13、Trpa1、G6pc、Actg2、Serpina3n。the homologous gene of corresponding in Drosophila：mGluRA、Orct2、CG6723、Nmdar1、Atypical protein kinase C、G protein alpha49B、Trpa1、CG15400、Act5c、Serine protease inhibitor 3。