The association between diabetes and mortality among patients hospitalized with COVID-19: Cohort Study of Hospitalized Adults in Ontario, Canada and Copenhagen, Denmark
The association between diabetes and mortality among patients hospitalized with COVID-19: Cohort Study of Hospitalized Adults in Ontario, Canada and Copenhagen, Denmark
Abstract ImportanceDiabetes has been reported to be associated with an increased risk of death among patients with COVID-19. However, available studies lack detail on COVID illness severity and measurement of relevant comorbidities. Design, Setting, and ParticipantsWe conducted a multicenter, retrospective cohort study of patients over the age of 18 years who were hospitalized with COVID-19 between January 1, 2020 and November 30, 2020 in Ontario, Canada and Copenhagen, Denmark. Chart abstraction emphasizing co-morbidities and disease severity was performed by trained research personnel. The association between diabetes and death was measured using Poissson regression. Main Outcomes and Measureswithin hospital 30-day risk of death. ResultsOur study included 1018 hospitalized patients with COVID-19 in Ontario and 305 in Denmark, of whom 405 and 75 patients respectively had pre-existing diabetes. In both Ontario and Denmark, patients with diabetes were more likely to be older, have chronic kidney disease, cardiovascular disease, higher troponin levels, and to receive antibiotics compared with adults who did not have diabetes. In Ontario, the crude mortality rate ratio among patients with diabetes was 1.60 [1.24 – 2.07 95% CI] and in the adjusted regression model was 1.19 [0.86 – 1.66 95% CI]. In Denmark, the crude mortality rate ratio among patients with diabetes was 1.27 (0.68 – 2.36 95% CI) and in the adjusted model was 0.87 (0.49 – 1.54 95% CI)]. Meta-analyzing the two rate ratios from each region resulted in a crude mortality rate ratio of 1.55 (95% CI 1.22,1.96) and an adjusted mortality rate ratio of 1.11 (95% CI 0.84, 1.47). ConclusionsPresence of diabetes was not strongly associated with in-hospital COVID mortality independent of illness severity and other comorbidities.
Zipursky Jonathan、Beaman Andrea、Detsky Allan、Barbosa David、Shaw Lauren Lapointe、Pearson Alexander、Perkins Bruce、Rothman Kenneth J.、Yarnell Chris、Sholzberg Michelle、Lovblom Erik、Quinn Kieran L.、Khaykin Yaariv、MacFadden Derek R.、Raissi Afsaneh、Gosset Alexi、Colacci Michael、Biering-S?rensen Tor、Hodzic-Santor Bena、Cressman Alex、Bogler Orly、Skaarup Kristoffer Grundtvig、Kandel Chris、H?jbjerg Lassen Mats、Fralick Mike、Weagle Rachael
Department of Medicine, University of Toronto, Temerty Faculty of MedicineTrillium Health PartnersDepartment of Medicine, University of Toronto, Temerty Faculty of Medicine||Sinai Health System, Department of Medicine, University of TorontoDepartment of Medicine, Southlake Regional Health CentreUniversity Health NetworkDepartment of Medicine, University of OttawaSinai Health System, Department of Medicine, University of TorontoDepartment of Epidemiology, School of Public Health, Boston UniversityInterdepartmental Division of Critical Care Medicine, University of TorontoDepartment of Medicine, University of Toronto, Temerty Faculty of Medicine||St Michael?ˉs Hospital, Unity Health TorontoSinai Health System, Department of Medicine, University of TorontoDepartment of Medicine, University of Toronto, Temerty Faculty of Medicine||Sinai Health System, Department of Medicine, University of Toronto||Interdepartmental Division of Palliative Care, Sinai Health System and University of TorontoDepartment of Medicine, Southlake Regional Health CentreThe Ottawa Hospital Research InstituteSinai Health System, Department of Medicine, University of TorontoDepartment of Medicine, University of Toronto, Temerty Faculty of Medicine||Sinai Health System, Department of Medicine, University of TorontoDepartment of Medicine, University of Toronto, Temerty Faculty of MedicineDepartment of Cardiology, University of CopenhagenDepartment of Medicine, University of Toronto, Temerty Faculty of Medicine||Sinai Health System, Department of Medicine, University of TorontoDepartment of Medicine, University of Toronto, Temerty Faculty of MedicineDepartment of Medicine, University of Toronto, Temerty Faculty of Medicine||Sinai Health System, Department of Medicine, University of TorontoDepartment of Cardiology, University of CopenhagenMichael Garron HospitalDepartment of Cardiology, University of CopenhagenDepartment of Medicine, University of Toronto, Temerty Faculty of Medicine||Sinai Health System, Department of Medicine, University of TorontoDepartment of Family Medicine, University of Ottawa
医药卫生理论医学研究方法内科学
Zipursky Jonathan,Beaman Andrea,Detsky Allan,Barbosa David,Shaw Lauren Lapointe,Pearson Alexander,Perkins Bruce,Rothman Kenneth J.,Yarnell Chris,Sholzberg Michelle,Lovblom Erik,Quinn Kieran L.,Khaykin Yaariv,MacFadden Derek R.,Raissi Afsaneh,Gosset Alexi,Colacci Michael,Biering-S?rensen Tor,Hodzic-Santor Bena,Cressman Alex,Bogler Orly,Skaarup Kristoffer Grundtvig,Kandel Chris,H?jbjerg Lassen Mats,Fralick Mike,Weagle Rachael.The association between diabetes and mortality among patients hospitalized with COVID-19: Cohort Study of Hospitalized Adults in Ontario, Canada and Copenhagen, Denmark[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2022.07.04.22276207.点此复制
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