EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF COVID-19 PATIENTS IN KENYA
EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF COVID-19 PATIENTS IN KENYA
Abstract BackgroundMore than 49,000 cases of infection and 900 deaths from COVID-19 have been recorded in the Kenya. However, the characteristics and risk factors for severe outcomes among hospitalized COVID-19 patients in this setting have not been described. MethodsWe extracted demographic, laboratory, clinical and outcome data from medical records of RT-PCR confirmed SARS-CoV2 patients admitted in six hospitals in Kenya between March and September, 2020. We used Cox proportional hazards regressions to determine factors related to in-hospital mortality. ResultsData from 787 COVID-19 patients was available. The median age was 43 years (IQR 30-53), with 505 (64%) males. At admission, 455 (58%) were symptomatic. The commonest symptoms were cough (337, 43%), loss of taste or smell (279, 35%), and fever (126, 16%). Co-morbidities were reported in 340 (43%), with cardiovascular disease, diabetes and HIV documented in 130 (17%), 116 (15%), 53 (7%) respectively. 90 (11%) were admitted to ICU for a mean of 11 days, 52 (7%) were ventilated with a mean of 10 days, 107 (14%) died. The risk of death increased with age [hazard ratio (HR) 1.57 (95% CI 1.13 – 2.19)] for persons >60 years compared to those <60 years old; having co-morbidities [HR 2.34 (1.68 – 3.25)]; and among males [HR 1.76 (1.27, 2.44)] compared to females. Elevated white blood cell count and aspartate aminotransferase were associated with higher risk of death. ConclusionsWe identify the risk factors for mortality that may guide stratification of high risk patients.
Ombajo Loice Achieng、Mutono Nyamai、Mutua Mbuvi、Wangai Frederick、Thumbi SM、Ali Loo Alliy Muhammad、Maritim Marybeth、Kamuri Evans、Sudi Paul、Munyu Waweru、Shah Reena、Odhiambo Jackline、Anzala Omu、Amoth Patrick、Juma Phoebe、Sood Mohammed
Department of Clinical Medicine and Therapeutics, College of Health Sciences, University of Nairobi||Centre for Epidemiological Modelling and Analysis, University of Nairobi||Unit of Infectious Diseases, Kenyatta National HospitalCentre for Epidemiological Modelling and Analysis, University of Nairobi||Washington State University, Global Health ProgramUnit of Infectious Diseases, Kenyatta National HospitalDepartment of Clinical Medicine and Therapeutics, College of Health Sciences, University of NairobiCentre for Epidemiological Modelling and Analysis, University of Nairobi||Paul G. Allen School for Global Animal Health, Washington State University||Institute of Immunology and Infection Research, Ashworth Laboratories, University of EdinburghUnit of Infectious Diseases, Kenyatta National HospitalDepartment of Clinical Medicine and Therapeutics, College of Health Sciences, University of NairobiUnit of Infectious Diseases, Kenyatta National HospitalUnit of Infectious Diseases, Kenyatta National HospitalAvenue HospitalDepartment of Medicine, Aga Khan University HospitalDepartment of Medicine, The Nairobi HospitalKAVI Institute of Clinical Research, University of NairobiMinistry of HealthDepartment of Clinical Medicine and Therapeutics, College of Health Sciences, University of Nairobi||Unit of Infectious Diseases, Kenyatta National HospitalDepartment of Medicine, Coast General Teaching and Referral Hospital
临床医学医学研究方法医药卫生理论
Ombajo Loice Achieng,Mutono Nyamai,Mutua Mbuvi,Wangai Frederick,Thumbi SM,Ali Loo Alliy Muhammad,Maritim Marybeth,Kamuri Evans,Sudi Paul,Munyu Waweru,Shah Reena,Odhiambo Jackline,Anzala Omu,Amoth Patrick,Juma Phoebe,Sood Mohammed.EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF COVID-19 PATIENTS IN KENYA[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2020.11.09.20228106.点此复制
评论