Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2
Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2
Abstract The Omicron SARS-CoV-2 has three distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 world-wide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we tested the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralized BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 were 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.
Kurhade Chaitanya、Liu Mingru、Xie Xuping、Ren Ping、Xia Hongjie、Zou Jing、Shi Pei-Yong
Department of Biochemistry and Molecular Biology, University of Texas Medical BranchDepartment of Pathology, University of Texas Medical BranchDepartment of Biochemistry and Molecular Biology, University of Texas Medical BranchDepartment of Pathology, University of Texas Medical BranchDepartment of Biochemistry and Molecular Biology, University of Texas Medical BranchDepartment of Biochemistry and Molecular Biology, University of Texas Medical BranchDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch||Sealy Institute for Drug Discovery, University of Texas Medical Branch||Institute for Human Infection and Immunity, University of Texas Medical Branch||Institute for Translational Sciences, University of Texas Medical Branch||Sealy Institute for Vaccine Sciences, University of Texas Medical Branch
医药卫生理论医学研究方法基础医学
Kurhade Chaitanya,Liu Mingru,Xie Xuping,Ren Ping,Xia Hongjie,Zou Jing,Shi Pei-Yong.Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2022.03.30.486409.点此复制
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