Untangling stability and gain modulation in cortical circuits with multiple interneuron classes
Untangling stability and gain modulation in cortical circuits with multiple interneuron classes
Abstract Synaptic inhibition is the mechanistic backbone of a suite of cortical functions, not the least of which are maintaining network stability and modulating neuronal gain. In cortical models with a single inhibitory neuron class, network stabilization and gain control work in opposition to one another – meaning high gain coincides with low stability and vice versa. It is now clear that cortical inhibition is diverse, with molecularly distinguished cell classes having distinct positions within the cortical circuit. We analyze circuit models with pyramidal neurons (E) as well as parvalbumin (PV) and somatostatin (SOM) expressing interneurons. We show how in E – PV – SOM recurrently connected networks an SOM-mediated modulation can lead to simultaneous increases in neuronal gain and network stability. Our work exposes how the impact of a modulation mediated by SOM neurons depends critically on circuit connectivity and the network state.
Miehl Christoph、Bos Hannah、Oswald Anne-Marie、Doiron Brent
Department of Neurobiology, University of Chicago||Grossman Center for Quantitative Biology and Human Behavior, University of ChicagoDepartment of Mathematics, University of PittsburghDepartment of Neurobiology, University of Chicago||Grossman Center for Quantitative Biology and Human Behavior, University of ChicagoDepartment of Mathematics, University of Pittsburgh||Department of Neurobiology, University of Chicago||Grossman Center for Quantitative Biology and Human Behavior, University of Chicago||Department of Neuroscience, University of Pittsburgh||Department of Statistics, University of Chicago
生物科学理论、生物科学方法系统科学、系统技术控制理论、控制技术
Miehl Christoph,Bos Hannah,Oswald Anne-Marie,Doiron Brent.Untangling stability and gain modulation in cortical circuits with multiple interneuron classes[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2020.06.15.148114.点此复制
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