Socioeconomic changes predict genome-wide DNA methylation in childhood
Socioeconomic changes predict genome-wide DNA methylation in childhood
Abstract Childhood socioeconomic position (SEP) is a major determinant of health and well-being across the entire life course. To effectively prevent and reduce health risks related to SEP, it is critical to better understand when and under what circumstances socioeconomic adversity shapes biological processes. DNA methylation (DNAm) is one such mechanism for how early life adversity “gets under the skin”. Using data from a large, longitudinal birth cohort, we showed that changes in the socioeconomic environment may influence DNAm at age 7. We also showed that middle childhood (ages 6-7) may be a potential sensitive period when socioeconomic instability, reflected in parental job loss, is especially important in shaping DNAm. Our findings highlight the importance of socioeconomic stability during childhood, providing biological evidence in support of public programs to help children and families experiencing socioeconomic instability and other forms of socioeconomic adversity during childhood.
Dunn Erin C.、Cerutti Janine、Lussier Alexandre A.、Smith Andrew D.A.C.、Liu Jiaxuan、Zhu Yiwen、Smith Brooke J.
Center for Genomic Medicine, Massachusetts General Hospital||Department of Psychiatry, Harvard Medical School||Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard||Harvard Center on the Developing Child, Harvard UniversityCenter for Genomic Medicine, Massachusetts General HospitalCenter for Genomic Medicine, Massachusetts General Hospital||Department of Psychiatry, Harvard Medical School||Stanley Center for Psychiatric Research, Broad Institute of MIT and HarvardMathematics and Statistics Research Group, University of the West of EnglandCenter for Genomic Medicine, Massachusetts General Hospital||Department of Epidemiology, Harvard T.H. Chan School of Public HealthCenter for Genomic Medicine, Massachusetts General Hospital||Department of Epidemiology, Harvard T.H. Chan School of Public HealthCenter for Genomic Medicine, Massachusetts General Hospital
预防医学基础医学生物科学研究方法、生物科学研究技术
Dunn Erin C.,Cerutti Janine,Lussier Alexandre A.,Smith Andrew D.A.C.,Liu Jiaxuan,Zhu Yiwen,Smith Brooke J..Socioeconomic changes predict genome-wide DNA methylation in childhood[EB/OL].(2025-03-28)[2025-04-26].https://www.medrxiv.org/content/10.1101/2021.06.23.21259418.点此复制
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