Galectin-3 as a potential prognostic biomarker of severe COVID-19 in SARS-CoV-2 infected patients
Galectin-3 as a potential prognostic biomarker of severe COVID-19 in SARS-CoV-2 infected patients
ABSTRACT BACKGROUNDPrognostic biomarkers are needed to identify patients at high-risk for severe COVID-19. Galectin-3 is known to drive neutrophil infiltration and release of pro-inflammatory cytokines contributing to airway inflammation. METHODSIn this prospective cohort, we assessed galectin-3 levels in 156 hospitalized patients with confirmed COVID-19. COVID-19 patients were diagnosed as either critical (>50% lung damage) or moderate (<50% of lung damage) based on computerized tomography. Patients who required invasive mechanical ventilation (IMV) and/or died during hospitalization were categorized as having a severe outcome, and a non-severe outcome if they were discharged and none of the former occurred. RESULTSElevated serum galectin-3 was significantly higher in critical patients compared to moderate ones (35.91 ± 19.37 ng/mL vs. 25 ± 14.85 ng/mL, p<0.0001). Patients who progressed to a severe outcome including IMV and/or in-hospital death, presented higher galectin-3 levels (41.17 ng/mL [IQR 29.71 – 52.25] vs. 23.76 ng/mL [IQR 15.78 – 33.97] compared to those of a non-severe outcome, p<0.0001). Galectin-3 discriminated well between those with severe and non-severe outcome, with an AUC of 0.75 (95% CI 0.67 – 0.84, p<0.0001) and was found to be an independent predictor of severe outcome regardless of the percentage of lung involvement. Additionally, the combination of galectin-3, CRP and albumin, significantly improved its individual predicting ability with an AUC 0.84 (95% CI 0.77 – 0.91, p<0.0001). CONCLUSIONCirculating galectin-3 levels can be used to predict severe outcomes in COVID-19 patients, including the requirement of mechanical ventilation and/or death, regardless of the initial severity of the disease.
Salgado-de la Mora Mois¨|s、Rodriguez-Alvarez F¨￠tima、Aguirre-Aguilar Eduardo、Escobar-Valderrama Juan Manuel、Torres-Ru¨az Jiram、Colborn Kathryn L、Kershenobich David、Alanis-Mendizabal Jorge、Huang Christene A、Rosa Nathaly Limon-de la、Navarro-Alvarez Nalu、G¨?mez-Mart¨an Diana、Vera-Maldonado Brenda I.、Palacios-Jim¨|nez Mildred、M¨|ndez-Guerrero Osvely、Tejeda-Dominguez Farid、Valdez-Sandoval Paola、Cervantes-Alvarez Eduardo
Instituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Internal MedicineInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Gastroenterology||Universidad VeracruzanaInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Internal MedicineInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Internal MedicineInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Immunology and RheumatologyDepartment of Surgery, University of Colorado Anschutz Medical CampusInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of GastroenterologyInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Internal MedicineDepartment of Surgery, University of Colorado Anschutz Medical CampusInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of GastroenterologyInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Gastroenterology||Universidad Panamericana School of Medicine||Department of Surgery, University of Colorado Anschutz Medical CampusInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Immunology and RheumatologyInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Gastroenterology||Universidad VeracruzanaInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Gastroenterology||Universidad VeracruzanaInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of GastroenterologyUniversidad Panamericana School of MedicineInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Internal MedicineInstituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n, Department of Gastroenterology||PECEM, Facultad de Medicina, Universidad Nacional Aut¨?noma de M¨|xico
医学研究方法基础医学临床医学
Salgado-de la Mora Mois¨|s,Rodriguez-Alvarez F¨￠tima,Aguirre-Aguilar Eduardo,Escobar-Valderrama Juan Manuel,Torres-Ru¨az Jiram,Colborn Kathryn L,Kershenobich David,Alanis-Mendizabal Jorge,Huang Christene A,Rosa Nathaly Limon-de la,Navarro-Alvarez Nalu,G¨?mez-Mart¨an Diana,Vera-Maldonado Brenda I.,Palacios-Jim¨|nez Mildred,M¨|ndez-Guerrero Osvely,Tejeda-Dominguez Farid,Valdez-Sandoval Paola,Cervantes-Alvarez Eduardo.Galectin-3 as a potential prognostic biomarker of severe COVID-19 in SARS-CoV-2 infected patients[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2021.02.07.21251281.点此复制
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