Effect of experimental hookworm infection on insulin resistance in people at risk of Type 2 Diabetes: a randomized, placebo-controlled trial
Effect of experimental hookworm infection on insulin resistance in people at risk of Type 2 Diabetes: a randomized, placebo-controlled trial
ABSTRACT The reduced prevalence of insulin resistance and type 2 diabetes (T2D) in countries with endemic parasitic worm infections suggests a protective role for worms against metabolic disorders, however clinical evidence has been non-existent. This 2-year randomized controlled trial of hookworm infection in 40 people at risk of T2D involved treatment with either 20 or 40 Necator americanus third-stage larvae (L3) or Placebo. Primary outcome was safety, with homeostatic model assessment of insulin resistance (HOMA-IR), fasting blood glucose (FBG), and body mass being the key metabolic outcomes. Adverse events were more frequent in hookworm-treated participants, where 44% experienced transient gastrointestinal symptoms. FBG and HOMA-IR were significantly lowered in both hookworm-treated groups at 1-year, and body mass was significantly lowered after L3-20 treatment at 2-years. Overall, hookworm infection was well tolerated in people at risk of T2D, and were associated with improved insulin resistance, warranting further exploration of the benefits of hookworms on metabolic health.
McDermott Robyn、Rahman Tony、Croese John、Merone Lea、Giacomin Paul R.、Pierce Doris R.、McDonald Malcolm、Lewis Chris、Becker Luke、Loukas Alex、Thompson Fintan、Field Matthew A.
Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University||University of South AustraliaThe Department of Gastroenterology and Hepatology, The Prince Charles HospitalCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook UniversityCollege of Health Sciences, James Cook UniversityCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook UniversityCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook UniversityCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook UniversityCollege of Health Sciences, James Cook UniversityCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook UniversityCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook UniversityCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University||University of South AustraliaCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University||College of Public Health, Medical & Vet Sciences, James Cook University||Immunogenomics Laboratory, Garvan Institute of Medical Research
医学研究方法预防医学基础医学
McDermott Robyn,Rahman Tony,Croese John,Merone Lea,Giacomin Paul R.,Pierce Doris R.,McDonald Malcolm,Lewis Chris,Becker Luke,Loukas Alex,Thompson Fintan,Field Matthew A..Effect of experimental hookworm infection on insulin resistance in people at risk of Type 2 Diabetes: a randomized, placebo-controlled trial[EB/OL].(2025-03-28)[2025-04-26].https://www.medrxiv.org/content/10.1101/2023.03.16.23287372.点此复制
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