New skill acquisition does not perturb existing function in sensory cortex
New skill acquisition does not perturb existing function in sensory cortex
Abstract The ability to learn and practice new skills applies to the computation of abstract properties such as geometric form and neuroprosthetic control, as well as physical actions. We trained adult mice to successfully use an optical brain-computer interface (BCI) device so that we could assess the extent to which abstract skill learning disrupts previously acquired cortical function. We found that animals used multiple neural strategies to gain volitional control of the BCI device, and continued to do so after additional training. Despite significant engagement of local neural activity during BCI performance, tuning properties and stimulus encoding were not perturbed by new skill acquisition. These results indicate that flexible selection of neural strategies during goal-directed practice may facilitate the integration of new skills with existing function.
Chase Steven M.、Kuhlman Sandra J.、Jeon Brian B.
Department of Biomedical Engineering, Carnegie Mellon University||Center for the Neural Basis of Cognition, Carnegie Mellon University||Neuroscience Institute, Carnegie Mellon UniversityDepartment of Biomedical Engineering, Carnegie Mellon University||Center for the Neural Basis of Cognition, Carnegie Mellon University||Neuroscience Institute, Carnegie Mellon University||Department of Biological Sciences, Carnegie Mellon UniversityDepartment of Biomedical Engineering, Carnegie Mellon University||Center for the Neural Basis of Cognition, Carnegie Mellon University||Neuroscience Institute, Carnegie Mellon University
生物科学研究方法、生物科学研究技术生理学生物物理学
Chase Steven M.,Kuhlman Sandra J.,Jeon Brian B..New skill acquisition does not perturb existing function in sensory cortex[EB/OL].(2025-03-28)[2025-05-12].https://www.biorxiv.org/content/10.1101/2021.02.08.430302.点此复制
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