Global organization of neuronal activity only requires unstructured local connectivity
Global organization of neuronal activity only requires unstructured local connectivity
Modern electrophysiological recordings simultaneously capture single-unit spiking activities of hundreds of neurons spread across large cortical distances. Yet this massively parallel activity is often confined to relatively low-dimensional manifolds. This implies strong coordination also among neurons that are most likely not even connected. Here, we combine in vivo recordings with network models and theory to characterize the nature of mesoscopic coordination patterns in macaque motor cortex and to expose their origin: We find that heterogeneity in local connectivity supports network states with complex long-range cooperation between neurons that arises from multi-synaptic, short-range connections. Our theory explains the experimentally observed spatial organization of covariances in resting state recordings as well as the behaviorally related modulation of covariance patterns during a reach-to-grasp task. The ubiquity of heterogeneity in local cortical circuits suggests that the brain uses the described mechanism to flexibly adapt neuronal coordination to momentary demands.
D?browska Paulina Anna、Gr¨1n Sonja、Helias Moritz、Deutz Lukas、Dahmen David、Layer Moritz、Brochier Thomas、von Papen Michael、Diesmann Markus、Voges Nicole、Riehle Alexa
Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research Centre||RWTH Aachen UniversityInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research Centre||Theoretical Systems Neurobiology, RWTH Aachen UniversityInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research Centre||Department of Physics, Faculty 1, RWTH Aachen UniversityInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research Centre||School of Computing, University of LeedsInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research CentreInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research Centre||RWTH Aachen UniversityInstitut de Neurosciences de la Timone (INT), CNRS - Aix-Marseille UniversityInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research CentreInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research Centre||Department of Physics, Faculty 1, RWTH Aachen University||Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine, RWTH Aachen UniversityInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research Centre||Institut de Neurosciences de la Timone (INT), CNRS - Aix-Marseille UniversityInstitute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA Institut Brain Structure-Function Relationships (INM-10), J¨1lich Research Centre||Institut de Neurosciences de la Timone (INT), CNRS - Aix-Marseille University
生物科学研究方法、生物科学研究技术生理学
D?browska Paulina Anna,Gr¨1n Sonja,Helias Moritz,Deutz Lukas,Dahmen David,Layer Moritz,Brochier Thomas,von Papen Michael,Diesmann Markus,Voges Nicole,Riehle Alexa.Global organization of neuronal activity only requires unstructured local connectivity[EB/OL].(2025-03-28)[2025-04-30].https://www.biorxiv.org/content/10.1101/2020.07.15.205013.点此复制
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