Disinfection effect of pulsed xenon ultraviolet irradiation on SARS-CoV-2 and implications for environmental risk of COVID-19 transmission
Disinfection effect of pulsed xenon ultraviolet irradiation on SARS-CoV-2 and implications for environmental risk of COVID-19 transmission
Abstract Prolonged survival of SARS-CoV-2 on environmental surfaces and personal protective equipment (PPE) may lead to these surfaces transmitting disease to others. This article reports the effectiveness of a pulsed xenon ultraviolet (PX-UV) disinfection system in reducing the load of SARS-CoV-2 on hard surfaces and N95 respirators. Chamber slides and N95 respirator material were directly inoculated with SARS-CoV-2 and exposed to different durations of PX-UV disinfection. For hard surfaces, disinfection for 1, 2, and 5 minutes resulted in 3.53 Log10, >4.54 Log10, and >4.12 Log10 reductions in viral load, respectively. For N95 respirators, disinfection for 5 minutes resulted in >4.79 Log10 reduction in viral load. We found that PX-UV significantly reduces SARS-CoV-2 on hard surfaces and N95 respirators. With the potential to rapidly disinfectant environmental surfaces and N95 respirators, PX-UV devices are a promising technology for the reduction of environmental and PPE bioburden and to enhance both HCW and patient safety by reducing the risk of exposure to SARS-CoV-2.
Alfson Kendra、Jinadatha Chetan、Jarvis William、Chemaly Roy F.、Khawaja Fareed、Povroznik Mark、Kaye Keith S、Sampathkumar Priya、Simmons Sarah、Carrion Ricardo Jr.、Jackson Stephanie、Stibich Mark、Staples Hilary、Rodriguez Robert M.
Department of Virology and Immunology, Texas Biomedical Research InstituteDepartment of Medicine, Central Texas Veterans Healthcare System||Department of Medicine, College of Medicine, Texas A&M Health Science CenterJason and Jarvis Associates, Hilton Head IslandDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer CenterDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer CenterDepartment of Quality, WVU Medicine: United Hospital CenterSchool of Medicine, Department of Infectious Diseases, University of MichiganMayo ClinicXenex Disinfection Services, Inc.Department of Virology and Immunology, Texas Biomedical Research InstituteDepartment of QualityXenex Disinfection Services, Inc.Department of Virology and Immunology, Texas Biomedical Research InstituteDepartment of Emergency Medicine, University of California San Francisco
预防医学环境科学理论微生物学
Alfson Kendra,Jinadatha Chetan,Jarvis William,Chemaly Roy F.,Khawaja Fareed,Povroznik Mark,Kaye Keith S,Sampathkumar Priya,Simmons Sarah,Carrion Ricardo Jr.,Jackson Stephanie,Stibich Mark,Staples Hilary,Rodriguez Robert M..Disinfection effect of pulsed xenon ultraviolet irradiation on SARS-CoV-2 and implications for environmental risk of COVID-19 transmission[EB/OL].(2025-03-28)[2025-08-17].https://www.medrxiv.org/content/10.1101/2020.05.06.20093658.点此复制
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