Pandemic Vibrio parahaemolyticus wave succession by gene loss
Pandemic Vibrio parahaemolyticus wave succession by gene loss
Abstract While the importance of spontaneous mutation and gene acquisition in the emergence and adaptive evolution of microbial pathogens is well recognized, the role of gene loss remains underexplored. Here, by large-scale phylogenomic analysis of 8,684 global isolates, we reconstructed the origin and evolutionary dynamics of the pandemic clone (PC) of Vibrio parahaemolyticus, the leading cause of seafood-associated infections worldwide. As has also been observed for the pandemic lineage of V. cholerae, there was an ‘explosive’ burst of gene and genomic island acquisition during the emergence of the clone followed by divergence into distinct, successive sublineages mediating waves of infections. In V. parahaemolyticus, a recent global wave succession event has been driven by gene-loss in the putrescine utilization (Puu) pathway, which confers phenotypic advantages related to environmental adaptation (enhanced biofilms) and human transmission (increased cell adhesion and intestinal colonization, reduced virulence in an animal model and milder clinical symptoms in humans), aligning with the trade-off hypothesis of pathogen virulence evolution. We identify similar lineage-specific Puu-gene-loss across multiple bacterial genera, with effects on biofilm and adhesion replicated in V. cholerae and E. coli, suggesting convergent evolution and universal mechanisms across bacteria. Our findings provide a novel paradigm of adaptative evolution by gene loss in a pandemic pathogen.
Wang Hui、Wang Jiancheng、Shi Xiaolu、Hu Qinghua、Zhou Zhemin、Yang Ruifu、Cui Yujun、Martinez-Urtaza Jaime、Falush Daniel、Svensson Sarah L.、Ni Chengpei、Lin Shuzhu、Yang Chao、Xie Li、Jia Zhizhou、Gao Song、Jiang Min、Wen Huiqi、Li Yinghui、Xu Wenxuan、Zhang Yiquan、Chao Yanjie、Qiu Hongling、Qin Yujiao
School of Public Health, Shanghai Jiao Tong University School of MedicineThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesShenzhen Center for Disease Control and PreventionShenzhen Center for Disease Control and PreventionKey Laboratory of Alkene-Carbon Fibers-Based Technology & Application for Detection of Major Infectious Diseases, Cancer Institute, Suzhou Medical College, Soochow UniversityState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and EpidemiologyState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and EpidemiologyDepartment of Genetics and Microbiology, Facultat de Bioci¨¨ncies, Universitat Aut¨°noma de BarcelonaThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesWuxi Center for Disease Control and PreventionThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesWuxi Center for Disease Control and PreventionShenzhen Center for Disease Control and PreventionThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesShenzhen Center for Disease Control and PreventionThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesDepartment of Clinical Laboratory, Nantong Third People?ˉs Hospital, Affiliated Nantong Hospital 3 of Nantong UniversityThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesSchool of Public Health, Shanghai Jiao Tong University School of MedicineThe Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences
微生物学生物科学研究方法、生物科学研究技术基础医学
Wang Hui,Wang Jiancheng,Shi Xiaolu,Hu Qinghua,Zhou Zhemin,Yang Ruifu,Cui Yujun,Martinez-Urtaza Jaime,Falush Daniel,Svensson Sarah L.,Ni Chengpei,Lin Shuzhu,Yang Chao,Xie Li,Jia Zhizhou,Gao Song,Jiang Min,Wen Huiqi,Li Yinghui,Xu Wenxuan,Zhang Yiquan,Chao Yanjie,Qiu Hongling,Qin Yujiao.Pandemic Vibrio parahaemolyticus wave succession by gene loss[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2024.06.03.596356.点此复制
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