The nucleus measures shape deformation for cellular proprioception and regulates adaptive morphodynamics
The nucleus measures shape deformation for cellular proprioception and regulates adaptive morphodynamics
Abstract The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints within their local environment remains largely unknown. Here we show that the nucleus, the biggest cellular organelle, functions as a non-dissipative cellular shape deformation gauge that enables cells to continuously measure shape variations on the time scale of seconds. Inner nuclear membrane unfolding together with the relative spatial intracellular positioning of the nucleus provides physical information on the amplitude and type of cellular shape deformation. This adaptively activates a calcium-dependent mechano-transduction pathway, controlling the level of actomyosin contractility and migration plasticity. Our data support that the nucleus establishes a functional module for cellular proprioception that enables cells to sense shape variations for adapting cellular behaviour to their microenvironment. One Sentence SummaryThe nucleus functions as an active deformation sensor that enables cells to adapt their behavior to the tissue microenvironment.
Pezzano Fabio、Colomer-Rosell Mariona、S¨￠nchez M¨?nica Marro、Tolosa-Ramon Queralt、Valverde Miguel A.、Wieser Stefan、Venturini Valeria、Jim¨|nez-Delgado Senda、H?kkinen Hanna-Maria、Krieg Michael、Castro Frederic Catal¨¤、Paz-L¨?pez Sonia、Ruprecht Verena、Loza-Alvarez Pablo
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyICFO ¨C Institut de Ciencies Fotoniques, The Barcelona Institute of Science and TechnologyICFO ¨C Institut de Ciencies Fotoniques, The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyLaboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF) BarcelonaICFO ¨C Institut de Ciencies Fotoniques, The Barcelona Institute of Science and TechnologyICFO ¨C Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology||Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyICFO ¨C Institut de Ciencies Fotoniques, The Barcelona Institute of Science and TechnologyICFO ¨C Institut de Ciencies Fotoniques, The Barcelona Institute of Science and TechnologyLaboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF) BarcelonaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology||Universitat Pompeu Fabra (UPF)ICFO ¨C Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology
细胞生物学生物物理学生物科学现状、生物科学发展
Pezzano Fabio,Colomer-Rosell Mariona,S¨￠nchez M¨?nica Marro,Tolosa-Ramon Queralt,Valverde Miguel A.,Wieser Stefan,Venturini Valeria,Jim¨|nez-Delgado Senda,H?kkinen Hanna-Maria,Krieg Michael,Castro Frederic Catal¨¤,Paz-L¨?pez Sonia,Ruprecht Verena,Loza-Alvarez Pablo.The nucleus measures shape deformation for cellular proprioception and regulates adaptive morphodynamics[EB/OL].(2025-03-28)[2025-05-03].https://www.biorxiv.org/content/10.1101/865949.点此复制
评论