flexLiTE: flexible micro-LED integrated optoelectrodes for long-term chronic deep-brain studies
flexLiTE: flexible micro-LED integrated optoelectrodes for long-term chronic deep-brain studies
Abstract Understanding complex neuronal circuitry and its functions of a living organism requires a specialized tool which is capable of recording a large ensemble of neuronal signals at single cell resolution and modulating neuronal activities selectively in the target region of brains with high spatiotemporal resolution, while sustaining long-term chronic operation without significant tissue degeneration or device shifts. We hereby present an ultra-flexible, minimally-invasive, Michigan-type neural probe for chronic opto-electrophysiology studies: flexLiTE (flexible micro-LED integrated optoelectrodes). flexLiTE incorporates monolithically integrated, soma-sized inorganic micro-LEDs (12 individually operated) and 32 recording electrodes. Both stimulation and recording modalities were achieved by stacking two modules on a flexible substrate: one with micro-LEDs for neuromodulation and the other with recording sites, resulting in a 115 μm-wide,12 μm-thick, 10 mm-long optoelectrode. From prototype devices, we demonstrated the reliable operation of flexLiTEs for recording and modulation of hippocampal neurons in a freely moving mice for over ～8 month.
Yoon Euisik、Lopez Ruiz Jose Roberto、V?r?slakos Mih¨￠ly、Hsieh Meng-Lin、Ko Eunah、Buzs¨￠ki Gy?rgy
Department of Electrical Engineering and Computer Science, University of Michigan||Department of Biomedical Engineering, University of Michigan||Department of Mechanical Engineering, University of Michigan||Center for Nanomedicine, Institute for Basic Science (IBS) and Graduate Program of Nano Biomedical Engineering (Nano BME), Advanced Science Institute, Yonsei UniversityDepartment of Electrical Engineering and Computer Science, University of MichiganNeuroscience Institute, Langone Medical Center, New York UniversityDepartment of Electrical Engineering and Computer Science, University of MichiganDepartment of Electrical Engineering and Computer Science, University of MichiganNeuroscience Institute, Langone Medical Center, New York University
光电子技术半导体技术生物科学现状、生物科学发展
Yoon Euisik,Lopez Ruiz Jose Roberto,V?r?slakos Mih¨￠ly,Hsieh Meng-Lin,Ko Eunah,Buzs¨￠ki Gy?rgy.flexLiTE: flexible micro-LED integrated optoelectrodes for long-term chronic deep-brain studies[EB/OL].(2025-03-28)[2025-04-24].https://www.biorxiv.org/content/10.1101/2022.08.05.503006.点此复制
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