Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
Abstract Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n=1157) and white matter integrity (n=1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy (FA) (β=-0.182, p=0.005). We also found reductions in FA in association/commissural fibres (β=-0.184, pcorrected=0.010) and thalamic radiations (β=-0.159, pcorrected=0.020). Tract-specific FA reductions were also found in the left superior longitudinal fasciculus (β=-0.194, pcorrected=0.025), superior thalamic radiation (β=-0.224, pcorrected=0.009) and forceps major (β=-0.193, pcorrected=0.025) in depression (all betas standardised). Our findings provide further evidence for disrupted white matter integrity in MDD.
Cox Simon R.、Liewald David C.、Smith Daniel J.、Deary Ian J.、McIntosh Andrew M.、Shen Xueyi、Reus Lianne M.、Whalley Heather C.、Bastin Mark E.、Adams Mark J.
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh||Department of Psychology, University of EdinburghDepartment of Psychology, University of EdinburghInstitute of Health and Wellbeing, Mental Health and Wellbeing Research Group, University of GlasgowCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh||Department of Psychology, University of EdinburghDivision of Psychiatry, University of Edinburgh, Edinburgh||Centre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghDivision of Psychiatry, University of Edinburgh, EdinburghDivision of Psychiatry, University of Edinburgh, EdinburghDivision of Psychiatry, University of Edinburgh, EdinburghCentre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghDivision of Psychiatry, University of Edinburgh, Edinburgh
神经病学、精神病学基础医学医学研究方法
Cox Simon R.,Liewald David C.,Smith Daniel J.,Deary Ian J.,McIntosh Andrew M.,Shen Xueyi,Reus Lianne M.,Whalley Heather C.,Bastin Mark E.,Adams Mark J..Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data[EB/OL].(2025-03-28)[2025-04-29].https://www.biorxiv.org/content/10.1101/070912.点此复制
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