Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Abstract Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We observed overproduction of acetate in an amount comparable to ketone bodies in patients and mice with diabetes or starvation. Mechanistically, ACOT 12&8 are dramatically upregulated in liver to convert FFA-derived acetyl-CoA to acetate and CoA. This conversion not only provides large amount of acetate which fuels brain preferentially rather than muscle, but also recycles CoA which is required for sustained fatty acid oxidation and ketogenesis. Taken together, we suggest that acetate is an emerging novel ketone body and may be used as a parameter to evaluate the progression of energy stress in the future.
Wen Yaxin、Ouyang Cong、Wang Huihui、Huang Huiying、Feng Liubin、Zhuo Yue、Li Qinxi、Wang Jinyang、Lin Donghai、Jiang Bin、Zhao Wentao、Ma Huanhuan、Yao Lizheng、Lin Furong、Zhang Yan、Shi Xiulin
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityHigh-Field NMR Center, College of Chemistry and Chemical Engineering, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityDepartment of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityDepartment of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University
生物化学基础医学生理学
Wen Yaxin,Ouyang Cong,Wang Huihui,Huang Huiying,Feng Liubin,Zhuo Yue,Li Qinxi,Wang Jinyang,Lin Donghai,Jiang Bin,Zhao Wentao,Ma Huanhuan,Yao Lizheng,Lin Furong,Zhang Yan,Shi Xiulin.Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses[EB/OL].(2025-03-28)[2025-06-08].https://www.biorxiv.org/content/10.1101/2023.03.23.533947.点此复制
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