Longitudinal to transverse metachronal wave transitions in an in-vitro model of ciliated bronchial epithelium
Longitudinal to transverse metachronal wave transitions in an in-vitro model of ciliated bronchial epithelium
Myriads of cilia beat on ciliated epithelia, which are ubiquitous in life. When ciliary beats are synchronized, metachronal waves emerge, whose direction of propagation depends on the living system in an unexplained way. We show on a reconstructed human bronchial epithelium in-vitro that the direction of propagation is determined by the ability of mucus to be transported at the epithelial surface. Numerical simulations show that longitudinal waves maximise the transport of mucus while transverse waves, observed when the mucus is rigid and still, minimize the energy dissipated by the cilia.
Viallat Annie、Gsell Simon、D?ˉOrtona Umberto、Loiseau Etienne、Favier Julien、Mesdjian Olivier、Wang Chenglei
Aix Marseille Univ, CNRS, CINAM, Turing Centre for Living systemsAix Marseille Univ, CNRS, Centrale MarseilleAix Marseille Univ, CNRS, Centrale MarseilleAix Marseille Univ, CNRS, CINAM, Turing Centre for Living systemsAix Marseille Univ, CNRS, Centrale MarseilleAix Marseille Univ, CNRS, CINAM, Turing Centre for Living systemsAix Marseille Univ, CNRS, Centrale Marseille
基础医学生理学生物物理学
Viallat Annie,Gsell Simon,D?ˉOrtona Umberto,Loiseau Etienne,Favier Julien,Mesdjian Olivier,Wang Chenglei.Longitudinal to transverse metachronal wave transitions in an in-vitro model of ciliated bronchial epithelium[EB/OL].(2025-03-28)[2025-06-13].https://www.biorxiv.org/content/10.1101/2021.10.28.466261.点此复制
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