Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice
Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice
ABSTRACT Oscillations, a highly conserved brain function across mammalian species, are pivotal in brain physiology and pathology. Traumatic brain injury (TBI) often leads to subacute and chronic brain oscillatory alterations associated with complications like post-traumatic epilepsy (PTE) in patients and animal models. Our recent work longitudinally recorded local field potential from the contralateral hippocampus of 12 strains of recombinant inbred Collaborative Cross (CC) mice alongside classical laboratory inbred C57BL/6J mice after lateral fluid percussion injury. In this study, we profiled the acute (<12 hr post-injury) and subacute (12-48 hr post-injury) hippocampal oscillatory responses to TBI and evaluated their predictive value for PTE. We found dynamic high-amplitude rhythmic spikes with elevated power density and reduced entropy that prevailed during the acute phase in CC031 mice who later developed PTE. This characteristic early brain oscillatory alteration is absent in CC031 sham controls or other CC and reference C57BL/6J strains that did not develop PTE after TBI. Our work provides quantitative measures linking early brain oscillation to PTE at a population level in mice under controlled experimental conditions. These findings will offer insights into circuit mechanisms and potential targets for neuromodulatory intervention.
Shannon Tyler、Levine Noah、Dirickson Rina、Rajjoub Noora、Kokiko-Cochran Olga、Yi Yoon-Jae、Cotter Christopher、Shen Yiyun、Gu Bin、de Villena Fernando Pardo-Manuel
Department of Neuroscience, Ohio State UniversityElectrical and Computer Engineering Program, Ohio State UniversityDepartment of Neuroscience, Ohio State UniversityDepartment of Neuroscience, Ohio State UniversityDepartment of Neuroscience, Ohio State University||Institute for Behavioral Medicine Research, Ohio State University||Chronic Brain Injury Program, Ohio State UniversityDepartment of Neuroscience, Ohio State UniversityDepartment of Neuroscience, Ohio State University||Institute for Behavioral Medicine Research, Ohio State UniversityCollege of Veterinary Medicine, Ohio State UniversityDepartment of Neuroscience, Ohio State University||Chronic Brain Injury Program, Ohio State UniversityDepartment of Genetics, University of North Carolina||Lineberger Comprehensive Cancer Center, University of North Carolina
基础医学神经病学、精神病学生物科学研究方法、生物科学研究技术
Shannon Tyler,Levine Noah,Dirickson Rina,Rajjoub Noora,Kokiko-Cochran Olga,Yi Yoon-Jae,Cotter Christopher,Shen Yiyun,Gu Bin,de Villena Fernando Pardo-Manuel.Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice[EB/OL].(2025-03-28)[2025-07-16].https://www.biorxiv.org/content/10.1101/2024.04.05.588288.点此复制
评论