Fatty acid synthesis in satellite glial cell promotes regenerative growth in sensory neurons
Fatty acid synthesis in satellite glial cell promotes regenerative growth in sensory neurons
SUMMARY Peripheral sensory neurons switch to a regenerative state after nerve injury to enable axon regeneration and functional recovery. Whether satellite glial cells (SGC), which completely surround the neuronal soma, contribute to the regenerative responses remains unexplored. Here we defined the transcriptional profile of SGC and identified Fabp7/BLBP as a novel marker of SGC. We report that nerve injury changes gene expression in SGC, which is mostly related to lipid metabolism, specifically fatty acid synthesis and PPARα signaling. Conditional deletion of Fatty acid synthase (Fasn), the committed enzyme in de novo fatty acid synthesis in SGC impairs axon regeneration. Treatment with the PPARα agonist fenofibrate rescues axon regeneration in mice lacking Fasn in SGC. This results indicates that PPARα functions downstream of fatty acid synthesis in SGC to promote axon regeneration. These results identify fatty acid synthesis in SGC as a fundamental novel mechanism mediating axon regeneration in adult peripheral nerves.
Avraham Oshri、Deng Pan-Yue、Jones Sara、Cavalli Valeria、Klyachko Vitaly A.、Kuruvilla Rejji、Semenkovich Clay F.
Department of Neuroscience, Washington University School of MedicineDepartment of Cell Biology and Physiology, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of Medicine||Center of Regenerative Medicine, Washington University School of Medicine||Hope Center for Neurological Disorders, Washington University School of MedicineDepartment of Cell Biology and Physiology, Washington University School of MedicineDepartment of Biology, Johns Hopkins UniversityDivision of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine||Department of Cell Biology and Physiology, Washington University School of Medicine
基础医学神经病学、精神病学生物化学
Avraham Oshri,Deng Pan-Yue,Jones Sara,Cavalli Valeria,Klyachko Vitaly A.,Kuruvilla Rejji,Semenkovich Clay F..Fatty acid synthesis in satellite glial cell promotes regenerative growth in sensory neurons[EB/OL].(2025-03-28)[2025-05-25].https://www.biorxiv.org/content/10.1101/2019.12.13.874669.点此复制
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