Three-dimensional Printing of Customized Bioresorbable Airway Stents
Three-dimensional Printing of Customized Bioresorbable Airway Stents
Abstract Central airway obstruction is a life-threatening disorder causing a high physical and psychological burden to patients due to severe breathlessness and impaired quality of life. Standard-of-care airway stents are silicone tubes, which cause immediate relief, but are prone to migration, especially in growing patients, and require additional surgeries to be removed, which may cause further tissue damage. Customized airway stents with tailorable bioresorbability that can be produced in a reasonable time frame would be highly needed in the management of this disorder. Here, we report poly(D,L-lactide-co-ε-caprolactone) methacrylate blends-based biomedical inks and their use for the rapid fabrication of customized and bioresorbable airway stents. The 3D printed materials are cytocompatible and exhibit silicone-like mechanical properties with suitable biodegradability. In vivo studies in healthy rabbits confirmed biocompatibility and showed that the stents stayed in place for 7 weeks after which they became radiographically invisible. The developed biomedical inks open promising perspectives for the rapid manufacturing of the customized medical devices for which high precision, tuneable elasticity and predictable degradation are sought-after.
Studart Andr¨| R.、Coulter Fergal Brian、Masania Kunal、Geks Anna Karoline、Cadalbert Jasmin、Kleger Nicole、von Rechenberg Brigitte、Leroux Jean-Christophe、Brambilla Davide、Paunovi? Nevena、Rafsanjani Ahmad、R¨1ber Fabienne、Klein Karina、Franzen Daniel、Karol Agnieszka、Kronen Peter W.、Bao Yinyin、Luo Zhi
Complex materials, Department of Materials, ETH ZurichComplex materials, Department of Materials, ETH ZurichComplex materials, Department of Materials, ETH Zurich||Shaping Matter Lab, Faculty of Aerospace Engineering, TU DelftMusculoskeletal Research Unit, Vetsuisse Faculty, University of ZurichInstitute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH ZurichComplex materials, Department of Materials, ETH ZurichMusculoskeletal Research Unit, Vetsuisse Faculty, University of ZurichInstitute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH ZurichInstitute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich||Faculty of Pharmacy, Universit¨| de Montr¨|alInstitute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH ZurichComplex materials, Department of Materials, ETH Zurich||The Maersk Mc-Kinney Moller Institute, University of Southern DenmarkDepartment of Pulmonology, University Hospital ZurichMusculoskeletal Research Unit, Vetsuisse Faculty, University of ZurichDepartment of Pulmonology, University Hospital ZurichMusculoskeletal Research Unit, Vetsuisse Faculty, University of ZurichMusculoskeletal Research Unit, Vetsuisse Faculty, University of Zurich||Veterinary Anaesthesia Services-International||Center for Applied Biotechnology and Molecular Medicine, University of ZurichInstitute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH ZurichInstitute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich
医学研究方法生物工程学材料科学
Studart Andr¨| R.,Coulter Fergal Brian,Masania Kunal,Geks Anna Karoline,Cadalbert Jasmin,Kleger Nicole,von Rechenberg Brigitte,Leroux Jean-Christophe,Brambilla Davide,Paunovi? Nevena,Rafsanjani Ahmad,R¨1ber Fabienne,Klein Karina,Franzen Daniel,Karol Agnieszka,Kronen Peter W.,Bao Yinyin,Luo Zhi.Three-dimensional Printing of Customized Bioresorbable Airway Stents[EB/OL].(2025-03-28)[2025-04-30].https://www.biorxiv.org/content/10.1101/2020.09.12.294751.点此复制
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