Atypical intrinsic neural timescales in temporal lobe epilepsy
Atypical intrinsic neural timescales in temporal lobe epilepsy
Abstract ObjectiveTemporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy in adults. Here, we aimed to profile local neural function in TLE in vivo, building on prior evidence that has identified widespread structural alterations. Using multimodal MRI, we mapped intrinsic neural timescales (INT) at rest, examined associations to TLE-related structural compromise, and evaluated the clinical utility of INT. MethodsWe studied 46 TLE patients and 44 healthy controls from two independent sites, and mapped INT changes in patients relative to controls across hippocampal, subcortical, and neocortical regions. We examined region-specific associations to structural alterations and explored effects of age and epilepsy duration. A supervised machine learning paradigm assessed utility of INT for classifying patients-vs-controls and seizure focus lateralization. ResultsRelative to controls, TLE showed marked INT reductions across multiple regions bilaterally, indexing faster changing resting activity, with strongest effects in ipsilateral medial and lateral temporal regions, and sensorimotor cortices. Findings were consistent in each site and robust, albeit with reduced effect sizes, when correcting for structural alterations. TLE-related INT reductions increased with advancing disease duration, yet findings differed from aging effects seen in controls. Classifiers based on INT distinguished patients-vs-controls (balanced accuracy, 5-fold: 76±2.65%; cross-site, 72-83%) and lateralized the focus in TLE (balanced accuracy, 5-fold: 96±2.10%; cross-site, 95-97%) with high accuracies and generalization. ConclusionsOur findings robustly demonstrate atypical macroscale function in TLE in a topography that extends beyond mesiotemporal epicenters. INT measurements can assist in TLE diagnosis, seizure focus lateralization, and monitoring of disease progression, which suggests clinical utility.
Park Bo-yong、Auer Hans、Caciagli Lorenzo、Concha Luis、Abdallah Chifaou、Xie Ke、Bernasconi Neda、Vos de Wael Reinder、Lariviere Sara、Bassett Dani S.、Royer Jessica、Bernasconi Andrea、Tavakol Shahin、Frauscher Birgit、Bernhardt Boris C.、Rodriguez-Cruces Raul、DeKraker Jordan
Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University||Department of Data Science, Inha University||Center for Neuroscience Imaging Research, Institute for Basic ScienceMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityDepartment of Biomedical Engineering, University of PennsylvaniaBrain Connectivity Laboratory, Institute of Neurobiology, Universidad Nacional Aut¨?noma de Mexico (UNAM)Analytical Neurophysiology Laboratory, Montreal Neurological Institute, McGill UniversityMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityDepartment of Biomedical Engineering, University of Pennsylvania||Department of Physics and Astronomy, University of Pennsylvania||Department of Electrical and Systems Engineering, University of Pennsylvania||Department of Neurology, University of Pennsylvania, Philadelphia||Department of Psychiatry, University of Pennsylvania||Santa Fe InstituteMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityAnalytical Neurophysiology Laboratory, Montreal Neurological Institute, McGill UniversityMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill UniversityMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
神经病学、精神病学基础医学医学研究方法
Park Bo-yong,Auer Hans,Caciagli Lorenzo,Concha Luis,Abdallah Chifaou,Xie Ke,Bernasconi Neda,Vos de Wael Reinder,Lariviere Sara,Bassett Dani S.,Royer Jessica,Bernasconi Andrea,Tavakol Shahin,Frauscher Birgit,Bernhardt Boris C.,Rodriguez-Cruces Raul,DeKraker Jordan.Atypical intrinsic neural timescales in temporal lobe epilepsy[EB/OL].(2025-03-28)[2025-05-08].https://www.biorxiv.org/content/10.1101/2022.07.01.498416.点此复制
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