Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation
Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation
Abstract Anorexia nervosa (AN) is a complex and serious eating disorder, occurring in ~1% of individuals. Despite having the highest mortality rate of any psychiatric disorder, little is known about the aetiology of AN, and few effective treatments exist. Global efforts to collect large sample sizes of individuals with AN have been highly successful, and a recent study consequently identified the first genome-wide significant locus involved in AN. This result, coupled with other recent studies and epidemiological evidence, suggest that previous characterizations of AN as a purely psychiatric disorder are over-simplified. Rather, both neurological and metabolic pathways may also be involved. In order to elucidate more of the system-specific aetiology of AN, we applied transcriptomic imputation methods to 3,495 cases and 10,982 controls, collected by the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). Transcriptomic Imputation (TI) methods approaches use machine-learning methods to impute tissue-specific gene expression from large genotype data using curated eQTL reference panels. These offer an exciting opportunity to compare gene associations across neurological and metabolic tissues. Here, we applied CommonMind Consortium (CMC) and GTEx-derived gene expression prediction models for 13 brain tissues and 12 tissues with potential metabolic involvement (adipose, adrenal gland, 2 colon, 3 esophagus, liver, pancreas, small intestine, spleen, stomach). We identified 35 significant gene-tissue associations within the large chromosome 12 region described in the recent PGC-ED GWAS. We applied forward stepwise conditional analyses and FINEMAP to associations within this locus to identify putatively causal signals. We identified four independently associated genes; RPS26, C12orf49, SUOX, and RDH16. We also identified two further genome-wide significant gene-tissue associations, both in brain tissues; REEP5, in the dorso-lateral pre-frontal cortex (DLPFC; p=8.52×10?07), and CUL3, in the caudate basal ganglia (p=1.8×10?06). These genes are significantly enriched for associations with anthropometric phenotypes in the UK BioBank, as well as multiple psychiatric, addiction, and appetite/satiety pathways. Our results support a model of AN risk influenced by both metabolic and psychiatric factors.
Tsitsika Artemis、Rayner N. William、Nilsson Ida、Slachtova Lenka、Burghardt Roland、Klareskog Lars、Egberts Karin、Metspalu Andres、Wade Tracey、Escaram¨as Ge¨°rgia、Norring Claes、Jur¨|us Anders、Kalsi Gursharan、Mitchell James、Mitchell Karen、Monteleone Alessio Maria、Ntalla Ioanna、O'Toole Julie、Parker Richard、Raevuori Anu、Reichborn-Kjennerud Ted、Rybakowski Filip、Dobbyn Amanda、McFadden Whitney、Ruderfer Douglas、Gamazon Eric、Lepp? Virpi、Adan Roger、Ando Tetsuya、Bergen Andrew、Berrettini Wade、Birgeg?rd Andreas、Cesta Carolyn、Crowley James、Davis Oliver、Degortes Daniela、DeSocio Janiece、Tozzi Federica、van Furth Eric、Walton Esther、Scott Laura、Soranzo Nicole、Southam Lorraine、Steen Vidar、H-Erich Wichmann、Kyung Im Hae、Sklar Pamela、Schork Nicholas、Schosser Alexandra、Seitz Jochen、Strober Michael、Szatkiewicz Jin、Tenconi Elena、Tortorella Alfonso、Angela Favaro、Dmitrzak-Weglarz Monika、Docampo Elisa、Ehrlich Stefan、Esko Tonu、Fern¨￠ndez-Aranda Fernando、Fischer Krista、Franklin Christopher、Gonidakis Fragiskos、Guo Yiran、Hakonarson Hakon、Hatzikotoulas Konstantinos、Hinney Anke、Hudson James、Huemer Julia、Kaminska Debora、Maj Mario、Mannik Katrin、Martin Nicholas、Kas Martien、Kennedy James、Keski-Rahkonen Anna、Klump Kelly、Levitan Robert、Li Dong、Lilenfeld Lisa、Yilmaz Zeynep、Zeggini Eleftheria、Cichon Sven、Ding Bo、Gallinger Steven、Gambaro Giovanni、Janout Vladimir、Leboyer Marion、Lundervold Astri J.、Zipfel Stephan、Lars Alfredsson、Aschauer Harald、Barrett Jeffrey、Palotie Aarno、Ripatti Samuli、Karhunen Leila、Tziouvas Konstantinos、Finan Chris、Merl Elisabeth、Boni Claudette、Sladek Robert、Le Hellard Stephanie、Smith Tosha、de Zwaan Martina、Wang Weiqing、Ole Andreassen、Navratilova Marie、Tachmazidou Ioanna、Micali Nadia、Rujescu Dan、Papezova Hana、Giegling Ina、McGuffin Peter、Kaye Walter、Rajewski Andrzej、Bulik Cynthia、Crawford Steven、Slof-Op ?ˉt Landt Margarita、Herzog Wolfgang、Danner Unna、Jim¨|nez-Murcia Susana、Estivill Xavier、Hebebrand Johannes、Pantel Jacques、Boraska Perica Vesna、Widen Elisabeth、Clementi Maurizio、Strengman Eric、Hendriks Judith、Cohen-Woods Sarah、Fichter Manfred、Coleman Joni、Zerwas Stephanie、Scherag Andr¨|、Foretova Lenka、Monica Gratacos、Rotondo Alessandro、Roberts Marion、Watson Hunna、Karwautz Andreas、Land¨|n Mikael、Espeseth Thomas、Kaprio Jaakko、Munn-Chernoff Melissa、Inoko Hidetoshi、Johnson Craig、Ritschel Franziska、Huckins Laura M.、Kim Youl-Ri、Yao Shuyang、van Elburg Annemarie、Dina Christian、Wagner Gudrun、Ophoff Roel、Santonastaso Paolo、Cassina Matteo、Mortensen Preben、Kaplan Allan、Crow Scott、Kennedy Martin、Cone Roger、Marsal Sara、Rabionet Raquel、La Via Maria、Herms Stefan、Kiezebrink Kirsty、Carlberg Laura、Treasure Janet、Mattingsdal Morten、Hilliard Christopher、Courtet Philippe、Forzan Monica、Bencko Vladimir、Woodside D. Blake、Juli¨￠ Antonio、Koeleman Bobby、Ramoz Nicolas、Knudsen Gun Peggy、Ricca Valdo、McDevitt Sara、Brandt Harry、Hauser Joanna、Gorwood Philip、Thornton Laura、Imgart Hartmut、Lichtenstein Paul、Szeszenia-Dabrowska Neonila、Floyd James、Monteleone Palmiero、Devlin Bernie、Sorbi Sandro、Meulenbelt Ingrid、Gaspar H¨|l¨|na、Herpertz-Dahlmann Beate、Sieberts Solveig K.、Helder Sietske、Cox Nancy、Scherer Stephen、Slagboom P. Eline、Baker Jessica、Schmidt Ulrike、Halmi Katherine、Magistretti Pierre、Dick Danielle、Slopien Agnieszka、Guillaume S¨|bastien、Ripke Stephan、Nacmias Benedetta、Sullivan Patrick、Stahl Eli A.、Koubek Doris、Lissowska Jolanta、Breen Gerome、Pinto Dalila、Dedoussis George、Dikeos Dimitris、Jordan Jenny
University of Athens ?°P. & A. Kyriakou?± Children?ˉs HospitalWellcome Trust Sanger Institute||Oxford Centre for Diabetes, Endocrinology and Metabolism||Wellcome Trust Centre for Human GeneticsDepartment of Molecular Medicine and Surgery, Karolinska Institutet||Center for Molecular Medicine, Karolinska University HospitalCharles UniversityKlinikum Frankfurt/OderKarolinska InstitutetUniversity Hospital of W¨1rzburgUniversity of TartuFlinders UniversityThe Barcelona Institute of Science and Technology||Universit?t Pompeu Fabra||Centro de Investigaci¨?n Biom¨|dica en Red en Epidemiolog¨aa y Salud P¨2blicaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County CouncilDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetKing?ˉs College LondonUniversity of North Dakota School of Medicine and Health SciencesVA Boston Healthcare System, Boston University School of MedicineUniversity of Campania ?°Luigi Vanvitelli?±Harokopio UniversityKartini ClinicQIMR Berghofer Medical Research InstituteUniversity of HelsinkiNorwegian Institute of Public Health, University of OsloInstitute of Psychiatry and Neurology, University of Social Sciences and HumanitiesPamela Sklar Division for Precision Psychiatry, Icahn School of Medicine at Mount Sinai||Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai||Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiPamela Sklar Division for Precision Psychiatry, Icahn School of Medicine at Mount Sinai||Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai||Department of Psychiatry, Icahn School of Medicine at Mount SinaiVanderbilt University Medical CenterVanderbilt University Medical Center||Section of Genetic Medicine, Department of Medicine, University of ChicagoCEDI ¨C Centre for Eating Disorders Innovation, Department of Medical Epidemiology and Biostatistics (MEB)University Medical Center Utrecht||Altrecht Eating Disorders RintveldNational Institute of Mental HealthBiorealm Research, Culver CityPerelman School of Medicine at the University of PennsylvaniaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet||Stockholm Health Care Services, Stockholm County CouncilKarolinska InstitutetUniversity of North Carolina at Chapel Hill||Karolinska InstitutetUniversity of BristolUniversity of PadovaSeattle University College of NursingUniversity of CyprusRivierduinen Eating Disorders Ursula, Leiden University Medical CenterDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden||Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU DresdenDepartment of Biostatistics, University of MichiganHuman Genetics, Wellcome Trust Sanger Institute||Department of Haematology, University of Cambridge||The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of CambridgeWellcome Trust Sanger Institute||Wellcome Trust Centre for Human GeneticsUniversity of Bergen, Haukeland University HospitalHelmholtz Centre Munich - German Research Center for Environmental HealthVanderbilt University Medical Center||Section of Genetic Medicine, Department of Medicine, University of ChicagoPamela Sklar Division for Precision Psychiatry, Icahn School of Medicine at Mount Sinai||Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai||Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai||Friedman Brain Institute, Icahn School of Medicine at Mount SinaiJ. Craig Venter InstituteMedical University of ViennaRWTH AachenUniversity of California at Los AngelesUniversity of North Carolina at Chapel HillUniversity of PadovaUniversity of Campania ?°Luigi Vanvitelli?±||University of PerugiaUniversity of PadovaPoznan University of Medical SciencesThe Barcelona Institute of Science and Technology||Universit?t Pompeu Fabra||CIBER Epidemiolog¨aa y Salud P¨2blicaDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine||Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU DresdenUniversity of Tartu, Broad InstituteUniversity Hospital of Bellvitge-IDIBELL and CIBEROBN, University of BarcelonaUniversity of TartuWellcome Trust Sanger InstituteNational and Kapodistrian University of AthensChildren?ˉs Hospital of PhiladelphiaChildren?ˉs Hospital of Philadelphia||University of PennsylvaniaWellcome Trust Sanger InstituteDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-EssenMcLean Hospital||Harvard Medical SchoolMedical University of ViennaCharles UniversityUniversity of Campania ?°Luigi Vanvitelli?±University of Tartu, University of LausanneQIMR Berghofer Medical Research InstituteUniversity of Groningen, University Medical Center UtrechtUniversity of TorontoUniversity of HelsinkiMichigan State UniversityUniversity of TorontoChildren?ˉs Hospital of PhiladelphiaAmerican School of Professional Psychology at Argosy UniversityUniversity of North Carolina at Chapel HillWellcome Trust Sanger InstituteUniversity Hospital BaselUniversity of California at San DiegoUniversity of TorontoColumbus-Gemelli University HospitalOstrava UniversityUniversit¨| Paris-Est-Cr¨|teil (UPEC)University of Bergen, K. G. Jebsen Center for Neuropsychiatric DisordersUniversity Medical Hospital TuebingenKarolinska InstitutetBiopsychosocial CorporationSanger InstituteMassachusetts General Hospital||Broad Institute||Massachusetts Institute of Technology||Harvard||Institute for Molecular MedicineUniversity of HelsinkiUniversity of Eastern Finland?°P. & A. Kyriakou?± Children?ˉs Hospital, PICUWellcome Trust Sanger InstituteMedical University of ViennaCentre of Psychiatry and NeuroscienceMcGill University||G¨|nome Qu¨|bec Innovation CentreUniversity of Bergen, Haukeland University HospitalUniversity of North Carolina at Chapel HillHannover Medical SchoolPamela Sklar Division for Precision Psychiatry, Icahn School of Medicine at Mount Sinai||Department of Genetics and Genomics, Icahn School of Medicine at Mount SinaiUniversity of Oslo||Oslo University HospitalMasaryk Memorial Cancer InstituteWellcome Trust Sanger InstituteUniversity of GenevaMartin Luther University of Halle-Wittenberg||Ludwig-Maximilians-University MunichCharles UniversityMartin Luther University of Halle-WittenbergKings College LondonUniversity of CaliforniaPoznan University of Medical SciencesUniversity of North Carolina at Chapel Hill||Karolinska InstitutetThe Center for Eating Disorders at Sheppard PrattRivierduinen Eating Disorders Ursula, Leiden University Medical CentreHeidelberg UniversityAltrecht Eating Disorders RintveldUniversity Hospital of Bellvitge-IDIBELL and CIBEROBN, University of BarcelonaCentre for Genomic Regulation (CRG)||The Barcelona Institute of Science and Technology||Universit?t Pompeu Fabra||Centro de Investigaci¨?n Biom¨|dica en Red en Epidemiolog¨aa y Salud P¨2blicaDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-EssenCentre de Psychiatrie et Neurosciences - Inserm U894Wellcome Trust Sanger Institute, University of Split School of MedicineInstitute for Molecular MedicineUniversity of PadovaDepartment of Pathology, University Medical Center Utrecht, The NetherlandsUniversity UtrechtFinders UniversityLudwig-Maximilians-University Munich, Sch?n Klinik RoseneckKing?ˉs College LondonUniversity of North Carolina at Chapel HillJena University HospitalMasaryk Memorial Cancer InstituteThe Barcelona Institute of Science and Technology||Universit?t Pompeu Fabra||Centro de Investigaci¨?n Biom¨|dica en Red en Epidemiolog¨aa y Salud P¨2blicaUniversity of PisaKing?ˉs College London||University of Auckland, New ZealandAbstract Anorexia nervosa (AN) is a complex and serious eating disorder, occurring in ~1% of individualsUniversity of North Carolina at Chapel Hill||School of Paediatrics and Child Health, Faculty of Medicine, Dentistry, and Life Sciences, The University of Western Australia||School of Psychology and Speech Pathology, Faculty of Health Sciences, Curtin UniversityMedical University of ViennaKarolinska Institutet, Gothenburg UniversityUniversity of Oslo||Oslo University HospitalUniversity of Helsinki, National Institute for Health and WelfareUniversity of North Carolina at Chapel HillTokai University School of MedicineEating Recovery CenterDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany, Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of MedicinePamela Sklar Division for Precision Psychiatry, Icahn School of Medicine at Mount Sinai||Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai||Department of Psychiatry, Icahn School of Medicine at Mount Sinai||Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai||Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount SinaiInje UniversityKarolinksa InstitutetCenter for Eating Disorders Rintveld||University of UtrechtUniversity of NantesMedical University of ViennaUniversity of California Los Angeles, University Medical Center UtrechtUniversity of PadovaUniversity of PadovaAarhus UniversityUniversity of TorontoUniversity of MinnesotaUniversity of OtagoUniversity of MichiganVail d'Hebron Hospital Research InstituteCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Universit?t Pompeu Fabra, Centro de Investigaci¨?n Biom¨|dica en Red en Epidemiolog¨aa y Salud P¨2blicaUniversity of North Carolina at Chapel HillUniversity of BaselUniversity of AberdeenMedical University of ViennaKing?ˉs College LondonOslo UniversityUniversity of North Carolina at Chapel HillCHRU Montpellier, University of MontpellierUniversity Hospital of PadovaCharles University, First Faculty of Medicine, Institute of Hygiene and EpidemiologyUniversity of Toronto, Toronto General HospitalVail d'Hebron Hospital Research InstituteUniversity Medical Center UtrechtCentre de Psychiatrie et Neurosciences - Inserm U894Norwegian Institute of Public HealthDepartment Neuroscience, Psychology, Drug Research and Child Health, University of FlorenceUniversity College Cork, Health Service Executive SouthThe Center for Eating Disorders at Sheppard PrattPoznan University of Medical SciencesINSERM U984, Sainte-Anne Hospital, University of Paris-DescartesUniversity of North Carolina at Chapel HillParkland-KlinikKarolinska InstitutetNofer Institute of Occupational Medicine, Department of Environmental EpidemiologyWellcome Trust Sanger Institute, Genomics PLCUniversity of SalernoDepartment of Psychiatry, University of PittsburghDepartment Neuroscience, Psychology, Drug Research and Child Health, University of Florence||IRCSS Fondazione Don Gnocchi, FlorenceLeiden University Medical CentreKing?ˉs College LondonRWTH AachenSystems Biology, Sage BionetworksZorg op Orde||King?ˉs College LondonSection of Genetic Medicine, Department of Medicine, University of ChicagoThe Hospital for Sick Children, University of TorontoLeiden University Medical CentreUniversity of North Carolina at Chapel HillKing?ˉs College LondonWeill Cornell Medical CollegeBrain Mind Institute, EPFL, Center for Psychiatric Neuroscience, Department of Psychiatry ¨C CHUV/UNILVirginia Commonwealth UniversityUniwersytet Medyczny im. Karola MarcinkowskiegoCHRU Montpellier, University of MontpellierCharit¨| Universt?tsmedizin BerlinDepartment Neuroscience, Psychology, Drug Research and Child Health, University of FlorenceUniversity of North Carolina at Chapel Hill||Karolinska InstitutetPamela Sklar Division for Precision Psychiatry, Icahn School of Medicine at Mount Sinai||Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount SinaiMedical University of ViennaM. Sklodowska-Curie Cancer Center and Institute of OncologyKing?ˉs College LondonDepartment of Genetics and Genomics, Icahn School of Medicine at Mount Sinai||Department of Psychiatry, Icahn School of Medicine at Mount SinaiHarokopio UniversityAthens University Medical SchoolUniversity of Otago||Canterbury District Health Board
医学研究方法神经病学、精神病学基础医学
Tsitsika Artemis,Rayner N. William,Nilsson Ida,Slachtova Lenka,Burghardt Roland,Klareskog Lars,Egberts Karin,Metspalu Andres,Wade Tracey,Escaram¨as Ge¨°rgia,Norring Claes,Jur¨|us Anders,Kalsi Gursharan,Mitchell James,Mitchell Karen,Monteleone Alessio Maria,Ntalla Ioanna,O'Toole Julie,Parker Richard,Raevuori Anu,Reichborn-Kjennerud Ted,Rybakowski Filip,Dobbyn Amanda,McFadden Whitney,Ruderfer Douglas,Gamazon Eric,Lepp? Virpi,Adan Roger,Ando Tetsuya,Bergen Andrew,Berrettini Wade,Birgeg?rd Andreas,Cesta Carolyn,Crowley James,Davis Oliver,Degortes Daniela,DeSocio Janiece,Tozzi Federica,van Furth Eric,Walton Esther,Scott Laura,Soranzo Nicole,Southam Lorraine,Steen Vidar,H-Erich Wichmann,Kyung Im Hae,Sklar Pamela,Schork Nicholas,Schosser Alexandra,Seitz Jochen,Strober Michael,Szatkiewicz Jin,Tenconi Elena,Tortorella Alfonso,Angela Favaro,Dmitrzak-Weglarz Monika,Docampo Elisa,Ehrlich Stefan,Esko Tonu,Fern¨￠ndez-Aranda Fernando,Fischer Krista,Franklin Christopher,Gonidakis Fragiskos,Guo Yiran,Hakonarson Hakon,Hatzikotoulas Konstantinos,Hinney Anke,Hudson James,Huemer Julia,Kaminska Debora,Maj Mario,Mannik Katrin,Martin Nicholas,Kas Martien,Kennedy James,Keski-Rahkonen Anna,Klump Kelly,Levitan Robert,Li Dong,Lilenfeld Lisa,Yilmaz Zeynep,Zeggini Eleftheria,Cichon Sven,Ding Bo,Gallinger Steven,Gambaro Giovanni,Janout Vladimir,Leboyer Marion,Lundervold Astri J.,Zipfel Stephan,Lars Alfredsson,Aschauer Harald,Barrett Jeffrey,Palotie Aarno,Ripatti Samuli,Karhunen Leila,Tziouvas Konstantinos,Finan Chris,Merl Elisabeth,Boni Claudette,Sladek Robert,Le Hellard Stephanie,Smith Tosha,de Zwaan Martina,Wang Weiqing,Ole Andreassen,Navratilova Marie,Tachmazidou Ioanna,Micali Nadia,Rujescu Dan,Papezova Hana,Giegling Ina,McGuffin Peter,Kaye Walter,Rajewski Andrzej,Bulik Cynthia,Crawford Steven,Slof-Op ?ˉt Landt Margarita,Herzog Wolfgang,Danner Unna,Jim¨|nez-Murcia Susana,Estivill Xavier,Hebebrand Johannes,Pantel Jacques,Boraska Perica Vesna,Widen Elisabeth,Clementi Maurizio,Strengman Eric,Hendriks Judith,Cohen-Woods Sarah,Fichter Manfred,Coleman Joni,Zerwas Stephanie,Scherag Andr¨|,Foretova Lenka,Monica Gratacos,Rotondo Alessandro,Roberts Marion,Watson Hunna,Karwautz Andreas,Land¨|n Mikael,Espeseth Thomas,Kaprio Jaakko,Munn-Chernoff Melissa,Inoko Hidetoshi,Johnson Craig,Ritschel Franziska,Huckins Laura M.,Kim Youl-Ri,Yao Shuyang,van Elburg Annemarie,Dina Christian,Wagner Gudrun,Ophoff Roel,Santonastaso Paolo,Cassina Matteo,Mortensen Preben,Kaplan Allan,Crow Scott,Kennedy Martin,Cone Roger,Marsal Sara,Rabionet Raquel,La Via Maria,Herms Stefan,Kiezebrink Kirsty,Carlberg Laura,Treasure Janet,Mattingsdal Morten,Hilliard Christopher,Courtet Philippe,Forzan Monica,Bencko Vladimir,Woodside D. Blake,Juli¨￠ Antonio,Koeleman Bobby,Ramoz Nicolas,Knudsen Gun Peggy,Ricca Valdo,McDevitt Sara,Brandt Harry,Hauser Joanna,Gorwood Philip,Thornton Laura,Imgart Hartmut,Lichtenstein Paul,Szeszenia-Dabrowska Neonila,Floyd James,Monteleone Palmiero,Devlin Bernie,Sorbi Sandro,Meulenbelt Ingrid,Gaspar H¨|l¨|na,Herpertz-Dahlmann Beate,Sieberts Solveig K.,Helder Sietske,Cox Nancy,Scherer Stephen,Slagboom P. Eline,Baker Jessica,Schmidt Ulrike,Halmi Katherine,Magistretti Pierre,Dick Danielle,Slopien Agnieszka,Guillaume S¨|bastien,Ripke Stephan,Nacmias Benedetta,Sullivan Patrick,Stahl Eli A.,Koubek Doris,Lissowska Jolanta,Breen Gerome,Pinto Dalila,Dedoussis George,Dikeos Dimitris,Jordan Jenny.Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation[EB/OL].(2025-03-28)[2025-06-30].https://www.biorxiv.org/content/10.1101/265017.点此复制
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