甘油三酯葡萄糖体质量指数、血浆致动脉粥样硬化指数与胆石症的相关性研究
orrelation between Triglyceride Glucose-body Mass Index, Atherogenic Index of Plasma and Gallstone Disease
目的 探讨甘油三酯葡萄糖体质量指数（triglyceride glucose-body mass index，TyG-BMI）、血浆致动脉粥样硬化指数（atherogenic index of plasma，AIP）与胆石症（gallstone disease, GSD）患病风险的相关性。方法 选取九江学院附属医院2023年1月~2023年12月经彩超、CT或MRI诊断为胆石症的395例患者作为胆石症组（GSD组），随机选取384例同期非胆石症患者作为对照组（Non-GSD组），收集临床资料，计算TyG-BMI、AIP指数。比较两组各项指标的差异，采用多因素Logistic回归分析TyG-BMI、AIP指数与GSD患病风险之间的关联性，受试者操作特征曲线（receiver operating characteristic curve，ROC曲线）评价TyG-BMI、AIP指数对GSD的预测价值。结果 两组的年龄、体质量指数（body mass index，BMI）、吸烟、饮酒、空腹血糖（fast blood glucose，FBG）、总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、高密度脂蛋白（high-density lipoprotein，HDL）、低密度脂蛋白（low density lipoprotein， LDL）、甘油三酯葡萄糖指数（triglyceride glucose，TyG）、TyG-BMI、AIP差异有统计学意义（P＜0.05），性别差异无统计学意义（P＞0.05）。单因素Logistic回归分析显示年龄、吸烟史、饮酒史、BMI、FBG、TG、LDL、TyG、TyG-BMI、AIP是GSD发病的危险因素，TC、HDL是GSD发病的保护因素（P＜0.05），性别不是GSD发病的影响因素（P＞0.05）。多因素Logistic回归分析显示年龄、FBG、TyG-BMI是GSD发病的独立危险因素（P＜0.05）。ROC曲线显示，TyG、TyG-BMI、AIP指数曲线下面积（area under the curve，AUC）分别为0.687（95%CI：0.650~0.724）、0.698（95%CI：0.662~0.734）、0.657（95%CI：0.619~0.695），TyG-BMI联合AIP的AUC为0.709（95%CI：0.673~0.745）。结论 TyG-BMI、AIP指数与胆石症的发病风险具有相关性，TyG-BMI是胆石症的独立危险因素，TyG-BMI、TyG-BMI联合AIP指数可作为胆石症的早期预测指标。
Objective To investigate the correlation between triglyceride glucose-body mass index (TyG-BMI), atherogenic index of plasma (AIP) and the risk of gallstone disease (GSD). Methods A total of 395 patients diagnosed with gallstone disease by color ultrasound, CT or MRI from January 2023 to December 2023 in the Affiliated Hospital of Jiujiang University were selected as the gallstone group (GSD group), and 384 patients with non-gallstone disease in the same period were randomly selected as the control group (Non-GSD group), and the clinical data were collected, and the TyG-BMI and AIP index were calculated. The differences of the indexes between the two groups were compared, multivariate Logistic regression was used to analyze the correlation between TyG-BMI and AIP index and the risk of GSD, and the receiver operating characteristic curve (ROC curve) was used to evaluate the predictive value of TyG-BMI and AIP index on GSD. Results There were statistically significant differences in age, body mass index (BMI), smoking history, alcohol history, fast blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride glucose (TyG), TyG-BMI, and AIP between the two groups (P<0.05), while gender difference was not statistically significant (P>0.05). Univariate Logistic regression analysis showed that age, smoking history, alcohol history, BMI, FBG, TG, LDL, TyG, TyG-BMI and AIP were risk factors for the onset of GSD, TC and HDL were protective factors for the onset of GSD (P<0.05), while gender was not the influencing factor for the incidence of GSD (P>0.05). Multivariate Logistic regression analysis showed that age, FBG, and TyG-BMI were independent risk factors for the onset of GSD (P<0.05). The ROC curves showed that the area under the curve (AUC) of TyG, TyG-BMI and AIP index were 0.687 (95%CI: 0.650~0.724), 0.698 (95%CI: 0.662~0.734) and 0.657 (95%CI: 0.619~0.695), respectively, and the AUC of TyG-BMI combined with AIP was 0.709 (95%CI: 0.673~0.745). Conclusion TyG-BMI and AIP index are correlated with the risk of gallstone disease, TyG-BMI is an independent risk factor for gallstone disease, and TyG-BMI and TyG-BMI combined with AIP index can be used as early predictors of gallstone disease.
童明富、刘慧敏
内科学基础医学临床医学
甘油三酯葡萄糖体质量指数血浆致动脉粥样硬化指数胰岛素抵抗胆石症相关性预测指标
riglyceride glucose-body mass indextherogenic index of plasmaInsulin resistanceGallstone diseaseorrelationPredictor
童明富,刘慧敏.甘油三酯葡萄糖体质量指数、血浆致动脉粥样硬化指数与胆石症的相关性研究[EB/OL].(2024-11-11)[2025-08-16].https://www.biomedrxiv.org.cn/article/doi/bmr.202411.00068.点此复制
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