“Injury-Prone”: Peripheral nerve injuries associated with prone positioning for COVID-19-related acute respiratory distress syndrome
“Injury-Prone”: Peripheral nerve injuries associated with prone positioning for COVID-19-related acute respiratory distress syndrome
Abstract Patients with Coronavirus disease 2019 (COVID-19) who require invasive mechanical ventilation frequently meet the acute respiratory distress syndrome (ARDS) diagnostic criteria. Hospitals based in the United States have been incorporating prone positioning (PP) into the COVID-19-related ARDS treatment plan at a higher rate than normal. Here, we describe 11 patients admitted to a single inpatient rehabilitation hospital who were subsequently diagnosed with acquired focal/multifocal peripheral nerve injury (PNI) in association with the use of PP for COVID-19-related ARDS. The reason for the high rate of PNI associated with PP in COVID-19 ARDS is likely multifactorial, but may include an underlying state of hyperinflammation and hypercoagulability already linked to other the neurological sequelae of COVID-19. Physicians must be aware of this elevated susceptibility to PNI in severe COVID-19 and refined standard PP protocols in order to reduce the risk.
Nussbaum Ryan P.、Ko Jason H.、Jayabalan Prakash、Walter James M.、Deshmukh Swati、Wolfe Alexis R.、Soriano Rachna、Malik George R.、Franz Colin K.、Rydberg Leslie、Wolfe Lisa F.
McGaw Medical Center, Northwestern University Feinberg School of Medicine||Shirley Ryan Ability Lab (Formerly the Rehabilitation Institute of Chicago)||Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of MedicineDivision of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of MedicineShirley Ryan Ability Lab (Formerly the Rehabilitation Institute of Chicago)||Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of MedicineThe Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of MedicineMcGaw Medical Center, Northwestern University Feinberg School of Medicine||The Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of MedicineShirley Ryan Ability Lab (Formerly the Rehabilitation Institute of Chicago)||Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of MedicineMcGaw Medical Center, Northwestern University Feinberg School of Medicine||Shirley Ryan Ability Lab (Formerly the Rehabilitation Institute of Chicago)||Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of MedicineShirley Ryan Ability Lab (Formerly the Rehabilitation Institute of Chicago)||Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine||The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of MedicineShirley Ryan Ability Lab (Formerly the Rehabilitation Institute of Chicago)||Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of MedicineThe Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine||The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine
临床医学神经病学、精神病学内科学
Nussbaum Ryan P.,Ko Jason H.,Jayabalan Prakash,Walter James M.,Deshmukh Swati,Wolfe Alexis R.,Soriano Rachna,Malik George R.,Franz Colin K.,Rydberg Leslie,Wolfe Lisa F..“Injury-Prone”: Peripheral nerve injuries associated with prone positioning for COVID-19-related acute respiratory distress syndrome[EB/OL].(2025-03-28)[2025-05-02].https://www.medrxiv.org/content/10.1101/2020.07.01.20144436.点此复制
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