Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis
Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis
Abstract BackgroundGuinea worm – Dracunculus medinensis – was historically one of the major parasites of humans and has been known since antiquity. Now, Guinea worm is on the brink of eradication, as efforts to interrupt transmission have reduced the annual burden of disease from millions of infections per year in the 1980s to only 30 human cases reported globally last year. Despite the enormous success of eradication efforts to date, one complication has arisen. Over the last few years, hundreds of dogs have been found infected with this previously apparently anthroponotic parasite, almost all in Chad. Moreover, the relative numbers of infections in humans and dogs suggests that dogs may be key in maintaining transmission in that country. ResultsIn an effort to shed light on this peculiar epidemiology of Guinea worm in Chad, we have sequenced and compared the genomes of worms from dog, human and other animal infections. Confirming previous work with other molecular markers, we show that all of these worms are D. medinensis, and that the same population of worms are causing both infections, can confirm the suspected transmission between host species and detect signs of a population bottleneck due to the eradication efforts. The diversity of worms in Chad appears to exclude the possibility that there were no, or very few, worms present in the country during a 10-year absence of reported cases. ConclusionsThis work reinforces the importance of adequate surveillance of both human and dog populations in the Guinea worm eradication campaign and suggests that control programs should stay aware of the possible emergence of unusual epidemiology as they approach elimination.
Durrant Caroline、Yibi Logora Makoy Samuel、Doyle Stephen R、Cotton James A.、Thiele Elizabeth A.、Tracey Alan、Tchindebet Ouakou、Huckvale Thomas、Abdellah Zahra、Foster Jeremy、Wossen Mesfin、Cleveland Christopher A.、Eberhard Mark L.、Weiss Adam、Ruiz-Tiben Ernesto、Yabsley Michael J.、Schulte-Hostedde Albrecht I、Lotkowska Magda E.、Coulibaly Cheick Oumar、Holroyd Nancy、Sankaranaranayan Geetha、Sall¨| Guillaume、Berriman Matthew、Bennett Hayley M.
Wellcome Sanger Institute, HinxtonThe Carter CenterWellcome Sanger Institute, HinxtonWellcome Sanger Institute, HinxtonDepartment of BiologyWellcome Sanger Institute, HinxtonThe Carter CenterWellcome Sanger Institute, HinxtonWellcome Sanger Institute, HinxtonNew England BiolabsThe Carter CenterUniversity of GeorgiaCenters for Disease Control and PreventionThe Carter CenterThe Carter CenterUniversity of GeorgiaDepartment of Biology, Laurentian UniversityWellcome Sanger Institute, HinxtonThe Carter CenterWellcome Sanger Institute, HinxtonWellcome Sanger Institute, HinxtonWellcome Sanger Institute, Hinxton||INRA - U. Tours, UMR 1282 ISP Infectiologie et Sant¨| PubliqueWellcome Sanger Institute, HinxtonWellcome Sanger Institute, Hinxton||Berkeley Lights Inc.
医学研究方法预防医学动物学
Durrant Caroline,Yibi Logora Makoy Samuel,Doyle Stephen R,Cotton James A.,Thiele Elizabeth A.,Tracey Alan,Tchindebet Ouakou,Huckvale Thomas,Abdellah Zahra,Foster Jeremy,Wossen Mesfin,Cleveland Christopher A.,Eberhard Mark L.,Weiss Adam,Ruiz-Tiben Ernesto,Yabsley Michael J.,Schulte-Hostedde Albrecht I,Lotkowska Magda E.,Coulibaly Cheick Oumar,Holroyd Nancy,Sankaranaranayan Geetha,Sall¨| Guillaume,Berriman Matthew,Bennett Hayley M..Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis[EB/OL].(2025-03-28)[2025-05-29].https://www.biorxiv.org/content/10.1101/808923.点此复制
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