Acute Myocardial Injury of Patients with Coronavirus Disease 2019
Acute Myocardial Injury of Patients with Coronavirus Disease 2019
Abstract BackgroundSince the outbreak of the Coronavirus Disease 2019 (COVID-19) in China, respiratory manifestations of the disease have been observed. However, as a fatal comorbidity, acute myocardial injury (AMI) in COVID-19 patients has not been previously investigated in detail. We investigated the clinical characteristics of COVID-19 patients with AMI and determined the risk factors for AMI in them. MethodsWe analyzed data from 53 consecutive laboratory-confirmed and hospitalized COVID-19 patients (28 men, 25 women; age, 19–81 years). We collected information on epidemiological and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, imaging findings, management methods, and clinical outcomes. ResultsCardiac complications were found in 42 of the 53 (79.25%) patients: tachycardia (n=15), electrocardiography abnormities (n=11), diastolic dysfunction (n=20), elevated myocardial enzymes (n=30), and AMI (n=6). All the six AMI patients were aged >60 years; five of them had two or more underlying comorbidities (hypertension, diabetes, cardiovascular diseases, and chronic obstructive pulmonary disease). Novel coronavirus pneumonia (NCP) severity was higher in the AMI patients than in patients with non-definite AMI (p<0.001). All the AMI patients required care in intensive care unit; of them, three died, two remain hospitalized. Multivariate analyses showed that C-reactive protein (CRP) levels, NCP severity, and underlying comorbidities were the risk factors for cardiac abnormalities in COVID-19 patients. ConclusionsCardiac complications are common in COVID-19 patients. Elevated CRP levels, underlying comorbidities, and NCP severity are the main risk factors for cardiac complications in COVID-19 patients.
Xu Rong、Liu Hui、Sun Ran、Zhao Shihua、Xu Huayan、Fu Hang、Guo Yingkun、Yang Ming、Zhang Na、Chen Huizhu、Yang Zhigang、Zhang Kun、Hou Keke、Xu Hong、Wen Lingyi、Li Zhenlin、Selvanayagam Joseph B.、Fu Chuan、Xie Linjun
Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Cardiac Imaging Center, Fuwai Hospital, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Respiratory Medicine, Public Health Clinical Center of ChengduDepartment of Radiology, Public Health Clinical Center of ChengduDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University||Department of Radiology, Public Health Clinical Center of ChengduDepartment of Ultrasonography, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Cardiovascular Medicine, Flinders Medical Centre, Flinders University of South AustraliaDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University
临床医学内科学医学研究方法
Xu Rong,Liu Hui,Sun Ran,Zhao Shihua,Xu Huayan,Fu Hang,Guo Yingkun,Yang Ming,Zhang Na,Chen Huizhu,Yang Zhigang,Zhang Kun,Hou Keke,Xu Hong,Wen Lingyi,Li Zhenlin,Selvanayagam Joseph B.,Fu Chuan,Xie Linjun.Acute Myocardial Injury of Patients with Coronavirus Disease 2019[EB/OL].(2025-03-28)[2025-04-30].https://www.medrxiv.org/content/10.1101/2020.03.05.20031591.点此复制
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