Reduced emergent character of neural dynamics in patients with a disrupted connectome
Reduced emergent character of neural dynamics in patients with a disrupted connectome
Abstract High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification of emergence for experimental data, neuroscientists have been unable to empirically test this long-standing conjecture. Here we investigate this fundamental question by leveraging a recently proposed framework known as “Integrated Information Decomposition,” which establishes a principled information-theoretic approach to operationalise and quantify emergence in dynamical systems — including the human brain. By analysing functional MRI data, our results show that the emergent and hierarchical character of neural dynamics is significantly diminished in chronically unresponsive patients suffering from severe brain injury. At a functional level, we demonstrate that emergence capacity is positively correlated with the extent of hierarchical organisation in brain activity. Furthermore, by combining computational approaches from network control theory and whole-brain biophysical modelling, we show that the reduced capacity for emergent and hierarchical dynamics in severely brain-injured patients can be mechanistically explained by disruptions in the patients’ structural connectome. Overall, our results suggest that chronic unresponsiveness resulting from severe brain injury may be due to structural impairment of the fundamental neural infrastructures required for brain dynamics to support emergence.
Luppi Andrea I.、Rosas Fernando E.、Craig Michael M.、Coppola Peter、Stamatakis Emmanuel A.、Williams Guy B.、Menon David K.、Bor Daniel、Peattie Alexander R.D.、Pickard John D.、Allanson Judith、Mediano Pedro A.M.、Finoia Paola
Division of Anaesthesia, School of Clinical Medicine, University of Cambridge||Department of Clinical Neurosciences, University of Cambridge||Leverhulme Centre for the Future of Intelligence||The Alan Turing InstituteCenter for Psychedelic Research, Department of Brain Science, Imperial College London||Data Science Institute, Imperial College London||Centre for Complexity Science, Imperial College London||Center for Eudaimonia and Human Flourishing, University of Oxford||Department of Informatics, University of SussexDivision of Anaesthesia, School of Clinical Medicine, University of Cambridge||Department of Clinical Neurosciences, University of CambridgeDivision of Anaesthesia, School of Clinical Medicine, University of Cambridge||Department of Clinical Neurosciences, University of CambridgeDivision of Anaesthesia, School of Clinical Medicine, University of Cambridge||Department of Clinical Neurosciences, University of CambridgeDepartment of Clinical Neurosciences, University of Cambridge||Wolfson Brain Imaging Centre, University of CambridgeDivision of Anaesthesia, School of Clinical Medicine, University of Cambridge||Wolfson Brain Imaging Centre, University of CambridgeDepartment of Psychology, University of Cambridge||Department of Psychology, Queen Mary University of LondonDivision of Anaesthesia, School of Clinical Medicine, University of Cambridge||Department of Clinical Neurosciences, University of CambridgeDepartment of Clinical Neurosciences, University of CambridgeDepartment of Clinical Neurosciences, University of Cambridge||Department of Neurosciences, Cambridge University Hospitals NHS Foundation, Addenbrooke?ˉs HospitalDepartment of Psychology, University of Cambridge||Department of Psychology, Queen Mary University of LondonDepartment of Clinical Neurosciences, University of Cambridge
神经病学、精神病学自然科学研究方法生物科学研究方法、生物科学研究技术
Luppi Andrea I.,Rosas Fernando E.,Craig Michael M.,Coppola Peter,Stamatakis Emmanuel A.,Williams Guy B.,Menon David K.,Bor Daniel,Peattie Alexander R.D.,Pickard John D.,Allanson Judith,Mediano Pedro A.M.,Finoia Paola.Reduced emergent character of neural dynamics in patients with a disrupted connectome[EB/OL].(2025-03-28)[2025-05-14].https://www.biorxiv.org/content/10.1101/2022.06.16.496445.点此复制
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