Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breastfeeding
Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breastfeeding
Abstract Although there have been many studies on antibody responses to SARS-CoV-2 in breastmilk, very few have looked at the fate of these in the baby. We carried out a study in 22 mother/baby pairs (mothers who breastfed and who were SARS-CoV-2 vaccinated before or after delivery) looking at mother blood, mother milk, baby blood, baby nose, and baby stool. Breastfed infants only acquired systemic anti-SARS-CoV-2 IgG antibodies if their mothers were vaccinated antepartum. None of the infants had SARS-CoV-2-specific IgA in the blood, but surprisingly, half of the infants in the Antepartum group had high titer SARS-CoV-2-specific IgA in the nose that exceeded titers found in breastmilk. Vaccination antepartum followed by breastfeeding appears to be the best way to provide systemic and local anti-SARS-CoV-2 antibodies for infants.
Parsell Dawn M.、Bor Casey、Campbell James D.、Tehrani Zahra Rikhtegaran、Lankford Allison、Levine Andrea R.、Grazioli Alison、Lewis George K.、Deatrick Kristopher B.、Shokatpour Narjes、Hammershaimb Elizabeth Adrianne、Herr Daniel L、Purcell Madeleine、Chertow Daniel S.、Sajadi Mohammad M.、Dugan Colleen、Bathula Allison、Ramelli Sabrina C.
University of Maryland School of MedicineUniversity of Maryland Medical CenterUniversity of Maryland School of MedicineInstitute of Human VirologyUniversity of Maryland School of MedicineUniversity of Maryland School of MedicineUniversity of Maryland School of MedicineInstitute of Human VirologyUniversity of Maryland School of MedicineInstitute of Human VirologyUniversity of Maryland School of MedicineUniversity of Maryland School of MedicineUniversity of Maryland School of MedicineNational Institutes of HealthVA Maryland Healthcare Center||Institute of Human VirologyUniversity of Maryland Medical CenterUniversity of Maryland Medical CenterNational Institutes of Health
预防医学妇产科学儿科学
Parsell Dawn M.,Bor Casey,Campbell James D.,Tehrani Zahra Rikhtegaran,Lankford Allison,Levine Andrea R.,Grazioli Alison,Lewis George K.,Deatrick Kristopher B.,Shokatpour Narjes,Hammershaimb Elizabeth Adrianne,Herr Daniel L,Purcell Madeleine,Chertow Daniel S.,Sajadi Mohammad M.,Dugan Colleen,Bathula Allison,Ramelli Sabrina C..Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breastfeeding[EB/OL].(2025-03-28)[2025-05-08].https://www.medrxiv.org/content/10.1101/2021.12.21.21267733.点此复制
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