Inter-individual differences in human brain structure and morphometry link to population variation in demographics and behavior
Inter-individual differences in human brain structure and morphometry link to population variation in demographics and behavior
Abstract We perform a comprehensive integrative analysis of multiple structural MR-based brain features and find strong evidence relating inter-individual structural variations to demographic and behavioral variates across a large cohort of healthy human volunteers. In particular, our findings shed some light on functional & structural integration, as we find a mode of structural variation that relates to and extends the ‘positive-negative’ behavioral spectrum which was recently reported as being associated with variations in functional connectivity. Significance statementThis work provides for the first-time strong evidence relating human brain structure variations to a wide range of demographic and behavioral measures. We show that several measures previously associated to variation in functional MRI connectivity are in fact already associated at the structural level, pointing towards structure-function integration.
Mulders P.、Llera A.、Beckmann C. F.、Wolfers T.
Donders Institute for Brain, Cognition and Behavior, Radboud University||Donders Centre for Cognitive Neuroimaging||Department of Cognitive Neuroscience, Radboud University Medical CentreDonders Institute for Brain, Cognition and Behavior, Radboud University||Donders Centre for Cognitive Neuroimaging||Department of Cognitive Neuroscience, Radboud University Medical CentreDonders Institute for Brain, Cognition and Behavior, Radboud University||Donders Centre for Cognitive Neuroimaging||Department of Cognitive Neuroscience, Radboud University Medical Centre||Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Oxford UniversityDonders Institute for Brain, Cognition and Behavior, Radboud University||Donders Centre for Cognitive Neuroimaging||Department of Cognitive Neuroscience, Radboud University Medical Centre
基础医学神经病学、精神病学生物科学研究方法、生物科学研究技术
Mulders P.,Llera A.,Beckmann C. F.,Wolfers T..Inter-individual differences in human brain structure and morphometry link to population variation in demographics and behavior[EB/OL].(2025-03-28)[2025-05-21].https://www.biorxiv.org/content/10.1101/413104.点此复制
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