Functional Organization of Midget and Parasol Ganglion Cells in the Human Retina
Functional Organization of Midget and Parasol Ganglion Cells in the Human Retina
ABSTRACT The functional organization of diverse retinal ganglion cell (RGC) types, which shapes the visual signal transmitted to the brain, has been examined in many species. The unique spatial, temporal, and chromatic properties of the numerically dominant RGC types in macaque monkey retina are presumed to most accurately model human vision. However, the functional similarity between RGCs in macaques and humans has only begun to be tested, and recent work suggests possible differences. Here, the properties of the numerically dominant human RGC types were examined using large-scale multi-electrode recordings with fine-grained visual stimulation in isolated retina, and compared to results from dozens of recordings from macaque retina using the same experimental methods and conditions. The properties of four major human RGC types -- ON-parasol, OFF-parasol, ON-midget, and OFF-midget -- closely paralleled those of the same macaque RGC types, including the spatial and temporal light sensitivity, precisely coordinated mosaic organization of receptive fields, ON-OFF asymmetries, spatial response nonlinearity, and sampling of photoreceptor inputs over space. Putative smooth monostratified cells and polyaxonal amacrine cells were also identified based on similarities to cell types previously identified in macaque retina. The results suggest that recently proposed differences between human and macaque RGCs probably reflect experimental differences, and that the macaque model provides an accurate picture of human RGC function.
Gogliettino Alex R.、Litke Alan M.、Sher Alexander、Wu Eric G.、Silva Ruwan A.、Chichilnisky E.J.、Kling Alexandra、Shah Nishal P.、Brackbill Nora
Neurosciences PhD Program, Stanford University||Hansen Experimental Physics Laboratory, Stanford UniversitySanta Cruz Institute for Particle Physics, University of CaliforniaSanta Cruz Institute for Particle Physics, University of CaliforniaDepartment of Electrical Engineering, Stanford University||Hansen Experimental Physics Laboratory, Stanford UniversityDepartment of Ophthalmology, Stanford UniversityDepartment of Neurosurgery, Stanford University||Department of Ophthalmology, Stanford University||Hansen Experimental Physics Laboratory, Stanford UniversityDepartment of Neurosurgery, Stanford University||Hansen Experimental Physics Laboratory, Stanford UniversityDepartment of Electrical Engineering, Stanford University||Hansen Experimental Physics Laboratory, Stanford UniversityDepartment of Physics, Stanford University||Hansen Experimental Physics Laboratory, Stanford University
细胞生物学生理学生物物理学
Gogliettino Alex R.,Litke Alan M.,Sher Alexander,Wu Eric G.,Silva Ruwan A.,Chichilnisky E.J.,Kling Alexandra,Shah Nishal P.,Brackbill Nora.Functional Organization of Midget and Parasol Ganglion Cells in the Human Retina[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2020.08.07.240762.点此复制
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