Replacement of the Gamma by the Delta variant in Brazil: impact of lineage displacement on the ongoing pandemic
Replacement of the Gamma by the Delta variant in Brazil: impact of lineage displacement on the ongoing pandemic
Abstract The COVID-19 epidemic in Brazil was driven mainly by the spread of Gamma (P.1), a locally emerged Variant of Concern (VOC) that was first detected in early January 2021. This variant was estimated to be responsible for more than 96% of cases reported between January and June 2021, being associated with increased transmissibility and disease severity, a reduction in neutralization antibodies and effectiveness of treatments or vaccines, as well as diagnostic detection failure. Here we show that, following several importations predominantly from the USA, the Delta variant rapidly replaced Gamma after July 2021. However, in contrast to what was seen in other countries, the rapid spread of Delta did not lead to a large increase in the number of cases and deaths reported in Brazil. We suggest that this was likely due to the relatively successful early vaccination campaign coupled with natural immunity acquired following prior infection with Gamma. Our data reinforces reports of the increased transmissibility of the Delta variant and, considering the increasing concern due to the recently identified Omicron variant, argues for the necessity to strengthen genomic monitoring on a national level to quickly detect and curb the emergence and spread of other VOCs that might threaten global health.
Kashima Simone、Holmes Edward C.、Fonseca Vagner、Althaus Christian L.、Xavier Joilson、Slavov Svetoslav Nanev、Ribeiro Gabriela、Coutinho Luiz Lehmann、Navegantes Wildo、do Carmo Said Rodrigo Fabiano、Elias Maria Carolina、Covas Dimas Tadeu、Louren?o Jose、de Alcantara Luiz Carlos Junior、de Oliveira Tulio、Wilkinson Eduan、Tegally Houriiyah、Viala Vincent Louis、Campelo de A e Melo Carlos F、Ranieri Jer?nimo Lima Alex、Venancio da Cunha Rivaldo、Fukumasu Heidge、San Emmanuel James、Sampaio Sandra Coccuzzo、Souza-Neto Jayme A.、Giovanetti Marta、Almiron Maria、Freitas Carla
University of S?o Paulo, Ribeir?o Preto Medical School, Blood Center of Ribeir?o PretoSydney Institute for Infectious Diseases, School of Life and Environmental Sciences and School of Medical Sciences, University of SydneyLaboratorio de Gen¨|tica Celular e Molecular, Instituto de Ci¨oncias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte||Organizac??J?o Pan-Americana da Sa¨2de/Organizac??J?o Mundial da Sa¨2de||KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal||Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University StellenboschInstitute of Social and Preventive Medicine, University of BernLaboratorio de Gen¨|tica Celular e Molecular, Instituto de Ci¨oncias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte||Laborat¨?rio Central de Sa¨2de P¨2blica do Estado de Minas GeraisUniversity of S?o Paulo, Ribeir?o Preto Medical School, Blood Center of Ribeir?o PretoButantan InstituteUniversity of S?o Paulo, Centro de Gen?mica Funcional da ESALQOrganizac??J?o Pan-Americana da Sa¨2de/Organizac??J?o Mundial da Sa¨2deOrganizac??J?o Pan-Americana da Sa¨2de/Organizac??J?o Mundial da Sa¨2deButantan InstituteUniversity of S?o Paulo, Ribeir?o Preto Medical School, Blood Center of Ribeir?o Preto||Butantan InstituteDepartment of Zoology, Peter Medawar Building, University of Oxford||Biosystems and Integrative Sciences Institute (BioISI), Universidade de LisboaLaboratorio de Flavivirus||Laboratorio de Gen¨|tica Celular e Molecular, Instituto de Ci¨oncias Biologicas, Universidade Federal de Minas Gerais, Belo HorizonteKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal||Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University Stellenbosch||Centre for the AIDS Programme of Research in South Africa (CAPRISA)||Department of Global Health, University of WashingtonKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal||Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University StellenboschKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-NatalButantan InstituteOrganizac??J?o Pan-Americana da Sa¨2de/Organizac??J?o Mundial da Sa¨2deButantan InstituteFunda??o Oswaldo CruzDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao PauloKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-NatalButantan InstituteS?o Paulo State University (UNESP), School of Agricultural SciencesLaboratorio de Flavivirus||Laboratorio de Gen¨|tica Celular e Molecular, Instituto de Ci¨oncias Biologicas, Universidade Federal de Minas Gerais, Belo HorizonteOrganizac??J?o Pan-Americana da Sa¨2de/Organizac??J?o Mundial da Sa¨2deCoordenac?o Geral dos Laborat¨?rios de Sa¨2de Publica/Secretaria de Vigilancia em Sa¨2de, Minist¨|rio da Sa¨2de, (CGLAB/SVS-MS) Bras¨alia
医药卫生理论医学现状、医学发展医学研究方法
Kashima Simone,Holmes Edward C.,Fonseca Vagner,Althaus Christian L.,Xavier Joilson,Slavov Svetoslav Nanev,Ribeiro Gabriela,Coutinho Luiz Lehmann,Navegantes Wildo,do Carmo Said Rodrigo Fabiano,Elias Maria Carolina,Covas Dimas Tadeu,Louren?o Jose,de Alcantara Luiz Carlos Junior,de Oliveira Tulio,Wilkinson Eduan,Tegally Houriiyah,Viala Vincent Louis,Campelo de A e Melo Carlos F,Ranieri Jer?nimo Lima Alex,Venancio da Cunha Rivaldo,Fukumasu Heidge,San Emmanuel James,Sampaio Sandra Coccuzzo,Souza-Neto Jayme A.,Giovanetti Marta,Almiron Maria,Freitas Carla.Replacement of the Gamma by the Delta variant in Brazil: impact of lineage displacement on the ongoing pandemic[EB/OL].(2025-03-28)[2025-05-05].https://www.medrxiv.org/content/10.1101/2021.12.27.21268309.点此复制
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