Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China
Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China
Summary COVID-19 is caused by the SARS-CoV-2 coronavirus and was first reported in central China in December 2019. Extensive molecular surveillance in Guangdong, China’s most populous province, during early 2020 resulted in 1,388 reported RNA positive cases from 1.6 million tests. In order to understand the molecular epidemiology and genetic diversity of SARS-CoV-2 in China we generated 53 genomes from infected individuals in Guangdong using a combination of metagenomic sequencing and tiling amplicon approaches. Combined epidemiological and phylogenetic analyses indicate multiple independent introductions to Guangdong, although phylogenetic clustering is uncertain due to low virus genetic variation early in the pandemic. Our results illustrate how the timing, size and duration of putative local transmission chains were constrained by national travel restrictions and by the province’s large-scale intensive surveillance and intervention measures. Despite these successes, COVID-19 surveillance in Guangdong is still required as the number of cases imported from other countries is increasing. Highlights1.6 million molecular diagnostic tests identified 1,388 SARS-CoV-2 infections in Guangdong Province, China, by 19th March 2020Virus genomes can be recovered using a variety of sequencing approaches from a range of patient samples.Genomic analyses reveal multiple virus importations into Guangdong Province, resulting in genetically distinct clusters that require careful interpretation.Large-scale epidemiological surveillance and intervention measures were effective in interrupting community transmission in Guangdong
Hill Verity、Peng Jingju、Song Tie、Xiong Qianlin、Xiao Jianpeng、Li Wei、Peng Bo、Fang Shisong、Su Wenzhe、bai Ru、Lin Huifang、Sun Jiufeng、Fran?ois Sarah、Kraemer Moritz U G、Faria Nuno R、Plessis Louis du、Liu Tao、Zeng Lilian、Yi Lina、Liu Jun、Quick Josh、Sun Ruilin、Ma Wenjun、Raghwani Jayna、Liu Zhe、Yuan Runyu、Rambaut Andrew、Liang Chuming、Zheng Huanying、Tang Xi、Pybus Oliver G、McCrone John T、Zhou Pingping、Liang Minfeng、Su Juan、Lu Jing、Kang Min、Li Kuibiao、Hu Jianxiong、Loman Nick、Ke Changwen
University of EdinburghGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Center for Disease Control and PreventionShenzhen Center for Disease Control and PreventionShenzhen Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionGuangdong Provincial Second People?ˉs HospitalGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionDepartment of Zoology, University of OxfordDepartment of Zoology, University of OxfordDepartment of Zoology, University of OxfordDepartment of Zoology, University of OxfordGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Center for Disease Control and PreventionInstitute of Microbiology and Infection, University of BirminghamGuangdong Provincial Second People?ˉs HospitalGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionDepartment of Zoology, University of OxfordGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionUniversity of EdinburghGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Center for Disease Control and PreventionFoshan First People?ˉs HospitalDepartment of Zoology, University of OxfordUniversity of EdinburghGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionFoshan First People?ˉs HospitalGuangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionGuangdong Provincial Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention||Guangdong Provincial Center for Disease Control and PreventionInstitute of Microbiology and Infection, University of BirminghamGuangdong Provincial Center for Disease Control and Prevention
医药卫生理论医学研究方法分子生物学
Hill Verity,Peng Jingju,Song Tie,Xiong Qianlin,Xiao Jianpeng,Li Wei,Peng Bo,Fang Shisong,Su Wenzhe,bai Ru,Lin Huifang,Sun Jiufeng,Fran?ois Sarah,Kraemer Moritz U G,Faria Nuno R,Plessis Louis du,Liu Tao,Zeng Lilian,Yi Lina,Liu Jun,Quick Josh,Sun Ruilin,Ma Wenjun,Raghwani Jayna,Liu Zhe,Yuan Runyu,Rambaut Andrew,Liang Chuming,Zheng Huanying,Tang Xi,Pybus Oliver G,McCrone John T,Zhou Pingping,Liang Minfeng,Su Juan,Lu Jing,Kang Min,Li Kuibiao,Hu Jianxiong,Loman Nick,Ke Changwen.Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China[EB/OL].(2025-03-28)[2025-04-29].https://www.medrxiv.org/content/10.1101/2020.04.01.20047076.点此复制
评论