Adaptive diversification through structural variation in barley
Adaptive diversification through structural variation in barley
Pangenomes are collections of annotated genome sequences of multiple individuals of a species. The structural variants uncovered by these datasets are a major asset to genetic analysis in crop plants. Here, we report a pangenome of barley comprising long-read sequence assemblies of 76 wild and domesticated genomes and short-read sequence data of 1,315 genotypes. An expanded catalogue of sequence variation in the crop includes structurally complex loci that have become hot spots of gene copy number variation in evolutionarily recent times. To demonstrate the utility of the pangenome, we focus on four loci involved in disease resistance, plant architecture, nutrient release, and trichome development. Novel allelic variation at a powdery mildew resistance locus and population-specific copy number gains in a regulator of vegetative branching were found. Expansion of a family of starch-cleaving enzymes in elite malting barleys was linked to shifts in enzymatic activity in micro-malting trials. Deletion of an enhancer motif is likely to change the developmental trajectory of the hairy appendages on barley grains. Our findings indicate that rapid evolution at structurally complex loci may have helped crop plants adapt to new selective regimes in agricultural ecosystems.
Zhang Xiao-Qi、Feser Manuel、Rasmussen Magnus Wohlfahrt、Feng Jia-Wu、Chalmers Kenneth、Jayakodi Murukarthick、Rabanus-Wallace M. Timothy、Jaegle Benjamin、Bekele Wubishet、Tibbits Josquin、Nielsen Martin Toft Simmelsgaard、Trautewig Corinna、Waugh Robbie、Westcott Sharon、Wicker Thomas、Dockter Christoph、Mascher Martin、Braune Katarzyna、Bunk Boyke、Fiebig Anne、Haberer Georg、Hansson Mats、Hoffie Iris、Hu Haifei、Keeble-Gagnere Gabriel、Koppolu Ravi、Li Chengdao、Maurer Andreas、Ramsay Luke、Pedas Pai Rosager、Sato Kazuhiro、Schueler Danuta、Schmutzer Thomas、Scholz Uwe、Schreiber Miriam、Shirasawa Kenta、Simpson Craig、Spannagl Manuel、Steffenson Brian、Muehlbauer Gary、Zhang Runxuan、Pillen Klaus、Lux Thomas、Voss Cynthia、Skadhauge Birgitte、Badea Ana、Keller Beat、Chapman Brett、Pin Pierre、Bayer Micha、Sakuma Shun、Stein Nils、Brar Gurcharn、Pidon Helene、Vequaud Dominique、Thomsen Hanne、Kumlehn Jochen、Knauft Manuela、Padmarasu Sudharsan、Krattinger Simon、Himmelbach Axel、Wang Penghao、Rutten Twan、Langridge Peter、Guo Yu、Perovic Dragan、Koenig Patrick、Kamal Nadia、Marone Marina、Gundlach Heidrun、Pozniak Curtis、Lu Qiongxian、Melzer Michael、Murozuka Emiko、Kale Sandip、Jorgensen Morten Egevang、Hoffie Robert、Guo Wenbin、Isobe Sachiko、Mayer Klaus
农业科学技术发展农业科学研究遗传学植物学
Zhang Xiao-Qi,Feser Manuel,Rasmussen Magnus Wohlfahrt,Feng Jia-Wu,Chalmers Kenneth,Jayakodi Murukarthick,Rabanus-Wallace M. Timothy,Jaegle Benjamin,Bekele Wubishet,Tibbits Josquin,Nielsen Martin Toft Simmelsgaard,Trautewig Corinna,Waugh Robbie,Westcott Sharon,Wicker Thomas,Dockter Christoph,Mascher Martin,Braune Katarzyna,Bunk Boyke,Fiebig Anne,Haberer Georg,Hansson Mats,Hoffie Iris,Hu Haifei,Keeble-Gagnere Gabriel,Koppolu Ravi,Li Chengdao,Maurer Andreas,Ramsay Luke,Pedas Pai Rosager,Sato Kazuhiro,Schueler Danuta,Schmutzer Thomas,Scholz Uwe,Schreiber Miriam,Shirasawa Kenta,Simpson Craig,Spannagl Manuel,Steffenson Brian,Muehlbauer Gary,Zhang Runxuan,Pillen Klaus,Lux Thomas,Voss Cynthia,Skadhauge Birgitte,Badea Ana,Keller Beat,Chapman Brett,Pin Pierre,Bayer Micha,Sakuma Shun,Stein Nils,Brar Gurcharn,Pidon Helene,Vequaud Dominique,Thomsen Hanne,Kumlehn Jochen,Knauft Manuela,Padmarasu Sudharsan,Krattinger Simon,Himmelbach Axel,Wang Penghao,Rutten Twan,Langridge Peter,Guo Yu,Perovic Dragan,Koenig Patrick,Kamal Nadia,Marone Marina,Gundlach Heidrun,Pozniak Curtis,Lu Qiongxian,Melzer Michael,Murozuka Emiko,Kale Sandip,Jorgensen Morten Egevang,Hoffie Robert,Guo Wenbin,Isobe Sachiko,Mayer Klaus.Adaptive diversification through structural variation in barley[EB/OL].(2025-03-28)[2025-05-16].https://www.biorxiv.org/content/10.1101/2024.02.14.580266.点此复制
评论