Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection
Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection
Abstract Antibody (Ab) responses to SARS-CoV-2 can be detected in most infected individuals 10-15 days following the onset of COVID-19 symptoms. However, due to the recent emergence of this virus in the human population it is not yet known how long these Ab responses will be maintained or whether they will provide protection from re-infection. Using sequential serum samples collected up to 94 days post onset of symptoms (POS) from 65 RT-qPCR confirmed SARS-CoV-2-infected individuals, we show seroconversion in >95% of cases and neutralizing antibody (nAb) responses when sampled beyond 8 days POS. We demonstrate that the magnitude of the nAb response is dependent upon the disease severity, but this does not affect the kinetics of the nAb response. Declining nAb titres were observed during the follow up period. Whilst some individuals with high peak ID50 (>10,000) maintained titres >1,000 at >60 days POS, some with lower peak ID50 had titres approaching baseline within the follow up period. A similar decline in nAb titres was also observed in a cohort of seropositive healthcare workers from Guy’s and St Thomas’ Hospitals. We suggest that this transient nAb response is a feature shared by both a SARS-CoV-2 infection that causes low disease severity and the circulating seasonal coronaviruses that are associated with common colds. This study has important implications when considering widespread serological testing, Ab protection against re-infection with SARS-CoV-2 and the durability of vaccine protection.
Batra Rahul、Kerridge Claire、Nebbia Gaia、Graham Carl、Merrick Blair、O?ˉBryne Aoife、Kouphou Neophytos、Galao Rui Pedro、Betancor Gilberto、Patel Amita、O?ˉConnell Lorcan、O?ˉHara Geraldine、Edgeworth Jonathan D.、Martinez Lauren、Honey Johanna、Malim Michael H.、Signell Adrian W.、Steel Kathyrn J.A.、Moore Amelia、Wilson Harry D.、Acors Sam、Snell Luke、Izquierdo-Barras Alba、Winstone Helena、Douthwaite Sam、Neil Stuart J.D.、Stokes Brielle、Hemmings Oliver、Seow Jeffrey、Bisnauthsing Karen、MacMahon Eithne、Arbane Gill、Doores Katie J、Pickering Suzanne、Martinez-Nunez Rocio、Temperton Nigel、Green Adrian
Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustCentre for Inflammation Biology and Cancer Immunology (CIBCI), Dept of Inflammation Biology, School of Immunology & Microbial Sciences, King?ˉs College LondonDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College London||Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustGuy?ˉs and St Thomas?ˉ R&D Department, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustGuy?ˉs and St Thomas?ˉ R&D Department, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonCentre for Inflammation Biology and Cancer Immunology (CIBCI), Dept of Inflammation Biology, School of Immunology & Microbial Sciences, King?ˉs College LondonCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustGuy?ˉs and St Thomas?ˉ R&D Department, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonGuy?ˉs and St Thomas?ˉ R&D Department, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King?ˉs College LondonDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustCentre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustCritical Care, St Thomas?ˉ Hospital, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King?ˉs College LondonViral Pseudotype Unit, Medway School of Pharmacy, University of KentGuy?ˉs and St Thomas?ˉ R&D Department, Guy?ˉs and St Thomas?ˉ NHS Foundation Trust
医药卫生理论医学研究方法基础医学
Batra Rahul,Kerridge Claire,Nebbia Gaia,Graham Carl,Merrick Blair,O?ˉBryne Aoife,Kouphou Neophytos,Galao Rui Pedro,Betancor Gilberto,Patel Amita,O?ˉConnell Lorcan,O?ˉHara Geraldine,Edgeworth Jonathan D.,Martinez Lauren,Honey Johanna,Malim Michael H.,Signell Adrian W.,Steel Kathyrn J.A.,Moore Amelia,Wilson Harry D.,Acors Sam,Snell Luke,Izquierdo-Barras Alba,Winstone Helena,Douthwaite Sam,Neil Stuart J.D.,Stokes Brielle,Hemmings Oliver,Seow Jeffrey,Bisnauthsing Karen,MacMahon Eithne,Arbane Gill,Doores Katie J,Pickering Suzanne,Martinez-Nunez Rocio,Temperton Nigel,Green Adrian.Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection[EB/OL].(2025-03-28)[2025-04-28].https://www.medrxiv.org/content/10.1101/2020.07.09.20148429.点此复制
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