Analog nitrogen sensing in Escherichia coli enables high fidelity information processing
Analog nitrogen sensing in Escherichia coli enables high fidelity information processing
Abstract The molecular reaction networks that coordinate the response of an organism to changing environmental conditions are central for survival and reproduction. Escherchia coli employs an accurate and flexible signalling system that is capable of processing ambient nitrogen availability rapidly and with high accuracy. Carefully orchestrated post-translational modifications of PII and the glutamine synthetase allow E. coli to trace nitrogen availability in a continuous, decidedly non-digital fashion. We measure the dynamic proteomic and metabolomic responses to trace the analog computations, and use an information theoretical framework to characterize the information capacity of E. coli’s nitrogen sensing network: we find that this system can transmit up to 9bits of information about the nitrogen state. This allows cells to respond rapidly and accurately even to small differences in metabolite concentrations.
Schumacher J.、Ale A.、Buck M.、Bennett Mark H.、Filippi S.、Komorowski M.、Stumpf M.P.H.、Jetka T.、Behrends V.、Pinney J.W.、Bundy J.G.
Department of Life Sciences, Faculty of Natural Sciences, Imperial College LondonDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London||Centre for Integrative Systems Biology and Bioinformatics, Imperial College LondonDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London||Centre for Integrative Systems Biology and Bioinformatics, Imperial College LondonDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College LondonDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London||Centre for Integrative Systems Biology and Bioinformatics, Imperial College LondonInstitute of Fundamental Technological Research, Polish Academy of SciencesDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London||Centre for Integrative Systems Biology and Bioinformatics, Imperial College London||Institute of Chemical Biology, Imperial College LondonInstitute of Fundamental Technological Research, Polish Academy of SciencesDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College LondonDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London||Centre for Integrative Systems Biology and Bioinformatics, Imperial College LondonDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London
分子生物学微生物学生物化学
Schumacher J.,Ale A.,Buck M.,Bennett Mark H.,Filippi S.,Komorowski M.,Stumpf M.P.H.,Jetka T.,Behrends V.,Pinney J.W.,Bundy J.G..Analog nitrogen sensing in Escherichia coli enables high fidelity information processing[EB/OL].(2025-03-28)[2025-06-29].https://www.biorxiv.org/content/10.1101/015792.点此复制
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