Objective, Quantitative, Data-Driven Assessment of Chemical Probes
Objective, Quantitative, Data-Driven Assessment of Chemical Probes
ABSTRACT Chemical probes are essential tools for understanding biological systems and for target validation, yet selecting tools for biomedical research is largely biased and subjective. Here we describe the Probe Miner: Chemical Probes Objective Assessment resource – capitalising on the plethora of public medicinal chemistry data to empower quantitative, objective, Big Data-driven assessment of chemical probes. We assess >1.8m compounds for their suitability as chemical tools against 2,220 human targets and dissect their biases and limitations.
Antolin Albert A.、Collins Ian、Workman Paul、Tym Joe E.、Al-Lazikani Bissan、Komianou Angeliki
Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics||Department of Data Science, The Institute of Cancer ResearchCancer Research UK Cancer Therapeutics Unit, Division of Cancer TherapeuticsCancer Research UK Cancer Therapeutics Unit, Division of Cancer TherapeuticsDepartment of Data Science, The Institute of Cancer ResearchCancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics||Department of Data Science, The Institute of Cancer Research||Department of Data Science, The Institute of Cancer Research
生物科学研究方法、生物科学研究技术药学生物化学
Antolin Albert A.,Collins Ian,Workman Paul,Tym Joe E.,Al-Lazikani Bissan,Komianou Angeliki.Objective, Quantitative, Data-Driven Assessment of Chemical Probes[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/168369.点此复制
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